Understanding risk factors in left ventricular non-compaction
Long Term Registry of Patients With Left Ventricular Non-Compaction and Predictors of Adverse Outcomes
This study looks at what factors might increase risks for people with left ventricular non-compaction and how these factors affect their heart health over time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Academic / other |
| Locations | 1 site (London, Ontario) |
| Trial ID | NCT06024759 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify risk factors and predictors of adverse outcomes in patients with left ventricular non-compaction (LVNC). It will investigate genetic mutations that may influence the development of ventricular arrhythmias, assess the role of left ventricular myocardial strain in risk stratification, and explore determinants of left ventricular dysfunction. Participants' medical records will be reviewed annually over ten years to gather data on the progression of LVNC and associated risks.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 with a confirmed diagnosis of left ventricular non-compaction.
Not a fit: Patients with other cardiomyopathies linked to genetic mutations or those without a confirmed diagnosis of LVNC will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved risk stratification and management strategies for patients with left ventricular non-compaction.
How similar studies have performed: While there is limited research specifically on LVNC, studies on other cardiomyopathies have shown success in identifying risk factors and improving patient outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria Patients must meet the following criteria in order to be included in the study. * Have a confirmed diagnosis of LVNC (between 2010-2020 for patients in the retrospective cohort only) * Be over 18 years of age Exclusion Criteria Patients are ineligible to participate in this study if they do not meet one or more of the inclusion criterion or if they have any other cardiomyopathy aside from LVNC that is linked to a genetic mutation they carry.
Where this trial is running
London, Ontario
- London Health Sciences Centre - University Hospital — London, Ontario, Canada (Recruiting)
Study contacts
- Study coordinator: Dr. Habib Khan
- Email: habib.khan@lhsc.on.ca
- Phone: 519-663-3746
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.