Clinical trial Recruiting at 1 site Observational Ages 18 and up

Understanding risk factors in left ventricular non-compaction

Official title: Long Term Registry of Patients With Left Ventricular Non-Compaction and Predictors of Adverse Outcomes

Run by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · NCT06024759 · Data updated 2026-11-12

This study looks at what factors might increase risks for people with left ventricular non-compaction and how these factors affect their heart health over time.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment500 (estimated)
SponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Academic / other
Locations1 site (London, Ontario)
StatusRecruiting
StartedSeptember 1, 2023
Main results expectedAugust 1, 2033
Study endsAugust 1, 2033
Registry record updatedNovember 1, 2023
Trial IDNCT06024759 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults over 18 with a confirmed diagnosis of left ventricular non-compaction.

Probably not a fit

Patients with other cardiomyopathies linked to genetic mutations or those without a confirmed diagnosis of LVNC will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify risk factors and predictors of adverse outcomes in patients with left ventricular non-compaction (LVNC). It will investigate genetic mutations that may influence the development of ventricular arrhythmias, assess the role of left ventricular myocardial strain in risk stratification, and explore determinants of left ventricular dysfunction. Participants' medical records will be reviewed annually over ten years to gather data on the progression of LVNC and associated risks.

Why it matters

Potential benefit: If successful, this study could lead to improved risk stratification and management strategies for patients with left ventricular non-compaction.

How similar studies have gone: While there is limited research specifically on LVNC, studies on other cardiomyopathies have shown success in identifying risk factors and improving patient outcomes.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria

Patients must meet the following criteria in order to be included in the study.

* Have a confirmed diagnosis of LVNC (between 2010-2020 for patients in the retrospective cohort only)
* Be over 18 years of age

Exclusion Criteria

Patients are ineligible to participate in this study if they do not meet one or more of the inclusion criterion or if they have any other cardiomyopathy aside from LVNC that is linked to a genetic mutation they carry.

Where it's running

  • London Health Sciences Centre - University Hospital
    London, Ontario, Canada
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.