Renal Nerve Stimulation to Help Blood Pressure in AF and HFpEF

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot, two-phase study explores the safety and feasibility of catheter-based renal artery electrical stimulation as a precursor to renal denervation. Phase 1 focuses on accessing the renal arteries and observing immediate blood pressure responses to brief stimulation in patients scheduled for electrophysiology studies or ablation. The study targets adults with atrial fibrillation, hypertension, and HFpEF, and excludes those with significant renal dysfunction or high-risk conditions. If safety and feasibility are demonstrated, subsequent phases would further evaluate the approach as a potential option to manage blood pressure in this patient group.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years
2. Scheduled for EP study +/- catheter ablation
3. Adequate renal function (eGFR ≥45 mL/min/1.73m²)

Exclusion Criteria:

1. Hemodynamic instability
2. Renal artery stenosis \>50%
3. Single functioning kidney
4. Previous renal artery intervention
5. Pregnancy or nursing
6. Life expectancy \<12 months
7. Unwilling or unable to provide informed consent
8. Participation in a clinical trial that may impact the outcomes of the current study

Where it's running

• London Heart Rhythm Program
  London, Ontario, Canada Recruiting

Study contacts

• Study coordinator: Megan Smith
• Email: meganj.smith@lhsc.on.ca
• Phone: 519-685-8500

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.