Investigating genetic factors in patients with neurodegenerative dementia
Investigating Genetic Status in Patients Presenting to Clinic
This study is trying to find out if certain genetic factors are linked to neurodegenerative dementias like Alzheimer's and Lewy Body dementia by looking at blood samples from patients and their family members.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Academic / other |
| Locations | 1 site (London, Ontario) |
| Trial ID | NCT05911932 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the genetic status of patients presenting with neurodegenerative dementias such as Alzheimer's disease, Frontotemporal dementia, and Lewy Body dementia. By collecting biosamples from individuals with suspected or confirmed diagnoses, as well as their biological family members, the study seeks to identify specific genetic mutations or polymorphisms associated with these conditions. The research focuses on understanding the genetic contributions to these diseases, which remain largely unknown. Participants must be 18 years or older and consent to a blood draw for genetic analysis.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 18 and older presenting with neurodegenerative disorders or biological family members of such patients.
Not a fit: Patients who decline or are unable to provide a blood sample will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the genetic underpinnings of neurodegenerative dementias, potentially leading to improved diagnostic and therapeutic strategies.
How similar studies have performed: Other studies have shown promise in identifying genetic factors in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Persons presenting to the cognitive clinic with a neurodegenerative disorder (for example, AD, FTD, LBD, ALSP, and related conditions); * Biological family members of someone diagnosed with a neurodegenerative disorder, presenting to clinic; * Age 18+ years old; * Consenting to a blood draw. Exclusion Criteria: • Persons declining / unwilling / not able to have a blood draw.
Where this trial is running
London, Ontario
- Parkwood Institute — London, Ontario, Canada (Recruiting)
Study contacts
- Principal investigator: Elizabeth Finger, MD — London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
- Study coordinator: Sarah Jesso
- Email: cognitiveneurology@sjhc.london.on.ca
- Phone: 519-646-6000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.