Comparing Heparin and Placebo in Patients Undergoing Cardiac Catheterization
Official title: A Randomized Trial of Heparin vs Placebo in Patients Undergoing Cardiac Catheterization Via the Trans-radial Approach
Run by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · NCT04374799 · Data updated 2026-11-12
This study is testing whether different doses of heparin can help prevent complications like bruising and artery blockage in patients getting a heart procedure through their wrist.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1623 (estimated) |
| Sponsor | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Academic / other |
| Locations | 2 sites (Hamilton, Ontario and 1 other locations) |
| Status | Recruiting |
| Started | October 5, 2020 |
| Main results expected | August 2026 |
| Study ends | December 2026 |
| Registry record updated | February 20, 2026 |
| Trial ID | NCT04374799 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients scheduled for diagnostic cardiac catheterization with a small size sheath and normal ulno-palmar circulation.
✕Probably not a fit
Patients with abnormal ulno-palmar circulation, prior radial artery thrombosis, or those requiring anticoagulation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effects of different doses of heparin compared to a placebo in patients undergoing diagnostic cardiac catheterization via the trans-radial approach. Participants will be randomly assigned to receive either low-dose heparin, high-dose heparin, or a saline placebo. The study aims to assess the incidence of hematoma and radial artery occlusion following the procedure. By evaluating these outcomes, the trial seeks to determine the optimal anticoagulation strategy for this patient population.
Why it matters
Potential benefit: If successful, this study could lead to improved safety and outcomes for patients undergoing cardiac catheterization.
How similar studies have gone: Other studies have explored anticoagulation strategies in cardiac procedures, suggesting potential benefits, but this specific approach is being tested for the first time.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * diagnostic cardiac catheterization; Small size sheath; patency of the ulno-palmar circulation Exclusion Criteria: abnormal ulno-palmar circulation; Prior radial artery thrombosis; Prior surgery close to the access site; Emergent cardiac catheterization; History of HIT or allergy to heparin; Patients requiring anticoagulation
Where it's running
-
Hamilton Health Sciences
Hamilton, Ontario, Canada Recruiting -
London Health Sciences Centre
London, Ontario, Canada Recruiting
Study contacts
- Study coordinator: Shahar Lavi, MD
- Email: Shahar.lavi@lhsc.on.ca
- Phone: 519-6633611
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.