Condition

Tricuspid Regurgitation clinical trials and research

• 37Clinical trials
• 2NIH research projects
• 26Countries

Newest Tricuspid Regurgitation clinical trials

All recruiting trials (37)

• 3D Echocardiography to See How CIEDs May Worsen Tricuspid Regurgitation

  This study tests whether different CIEDs (leadless pacemakers, LBBaP, and conventional pacemakers) differ in causing worsening tricuspid regurgitation, using 3D heart imaging.

  Recruiting Samsung Medical Center · Seoul, Seoul · NCT07793916

• Compare leadless and left bundle branch pacemakers for heart and valve function

  This study tests whether leadless pacemakers or left bundle branch area pacing better preserve heart and tricuspid valve function in adults needing a pacemaker.

  Recruiting Guy's and St Thomas' NHS Foundation Trust · London · NCT07534917

• TriClip for treating tricuspid regurgitation in Japan

  This study will see if the TriClip device is safe and helps people in Japan with symptomatic severe tricuspid regurgitation when used in routine clinical care.

  Recruiting Abbott Medical Devices · Suita, Osaka · NCT07509658

• Impact of transcatheter tricuspid valve repair on kidneys, strength, and activity in older adults

  This study will try catheter-based tricuspid valve repair (TEER) in older adults with severe symptomatic tricuspid regurgitation to see if kidney function, fluid overload, and physical activity improve.

  Recruiting Robert Bosch Medical Center · Stuttgart · NCT07464106

• TARGET 2.0: Cardiovalve TR replacement for tricuspid regurgitation

  This study will test a percutaneously delivered Cardiovalve tricuspid replacement via the femoral vein in adults with symptomatic severe secondary tricuspid regurgitation who are high risk for open-heart surgery.

  Recruiting Cardiovalve Ltd. · Bonn · NCT07334691

• Pivot Extend device to treat severe tricuspid regurgitation

  This trial will try the Pivot Extend device in adults with severe, symptomatic tricuspid regurgitation to see if it safely reduces valve leakage and improves symptoms.

  Recruiting Tau-MEDICAL Co., Ltd. · Macquarie Park, New South Wales · NCT07172477

• Early feasibility of the Laplace Transcatheter Tricuspid Valve Replacement — Canada

  This study tries the Laplace transcatheter tricuspid valve replacement to see if it is safe and can be successfully implanted in people aged 60–90 with severe, symptomatic tricuspid regurgitation who remain symptomatic despite optimal medical therapy.

  Recruiting at 3 sites Laplace Interventional, Inc · Ottawa, Ontario and 2 other locations · NCT07171060

• Transcatheter tricuspid annular repair for severe symptomatic functional tricuspid regurgitation

  This study will try a transcatheter annular therapy device in adults with severe, symptomatic functional tricuspid regurgitation to see if it is safe and can be placed successfully.

  Recruiting Tangent Cardiovascular Inc. · Asunción · NCT07140562

• Comprehensive imaging of valve regurgitation and recurrence risk after atrial fibrillation ablation

  This project will use 3D transesophageal and transthoracic echocardiography to try to find imaging signs that predict valve regurgitation and which adults with atrial fibrillation planning ablation are more likely to have recurrence.

  Recruiting First Hospital of China Medical University · Shenyang, Liaoning · NCT07085650

• Non-invasive testing to profile tricuspid regurgitation

  This project will test whether non-invasive tools like lung‑fluid monitoring (ReDs Pro) and liver FibroScan can better classify people with moderate-to-severe tricuspid regurgitation to guide care.

  Recruiting Prince of Wales Hospital, Shatin, Hong Kong · Hong Kong, Shatin · NCT07042360

• Improving predictions for transcatheter treatment of tricuspid valve issues

  This study is trying to see if using advanced scans can help doctors better predict how well catheter treatments will work for people with severe tricuspid valve problems.

  Recruiting Heart and Diabetes Center North-Rhine Westfalia · Bad Oeynhausen, North Rhine-Westphalia · NCT06951126

• Study on risk factors and outcomes in patients with tricuspid regurgitation

  This study looks at patients with tricuspid regurgitation in the hospital to see what factors affect their health outcomes and how likely they are to face serious issues or death.

  Recruiting Sun Yat-sen University · Guangzhou, Guangdong and 6 other locations · NCT06926959

• Evaluating tricuspid regurgitation progression in pacemaker patients

  This study looks at how tricuspid regurgitation gets worse over time in patients with pacemakers to see if different types of heart pacing affect their health outcomes.

  Recruiting Qianfoshan Hospital · Jinan · NCT06922526

• Two-year outcomes after TriClip repair for severe tricuspid regurgitation

  This project will see if adults with symptomatic severe tricuspid regurgitation who receive the TriClip repair have better two-year health outcomes than similar patients who do not get the repair.

  Recruiting Abbott Medical Devices · Santa Clara, California · NCT06920745

• Characterizing patients and outcomes in severe tricuspid regurgitation

  This study looks at people with severe tricuspid regurgitation to see who can get a new heart valve treatment and how well it works for them.

  Recruiting Medical University of Warsaw · Warsaw, Masovian Voivodeship · NCT06838611

• Understanding Atrioventricular Regurgitation in ATTR Amyloid Cardiomyopathy

  This study is trying to understand how common certain heart valve problems are in people with ATTR amyloid cardiomyopathy and create better ways to measure their severity.

  Recruiting at 8 sites Medical University of Vienna · Graz, Styria and 7 other locations · NCT06836011

• Evaluating long-term outcomes of patients with severe Tricuspid Regurgitation treated with the EVOQUE valve

  This study looks at how well the EVOQUE valve works for people with severe Tricuspid Regurgitation over two years compared to those who receive standard treatment.

  Recruiting Edwards Lifesciences · Irvine, California · NCT06833476

• Transcatheter Tricuspid Valve Replacement with the LuxValve Plus for High-Risk TR

  This trial tests whether replacing the tricuspid valve with the LuxValve Plus in adults aged 50–90 who have severe, symptom-persistent tricuspid regurgitation and are high risk for surgery can improve symptoms.

  Recruiting Prince of Wales Hospital, Shatin, Hong Kong · Hong Kong, Shatin · NCT06714500

• Registry for transcatheter repair of tricuspid regurgitation

  This study is collecting information on how well transcatheter repairs or replacements for the tricuspid valve work for people with tricuspid regurgitation to help improve treatment choices for them.

  Recruiting LMU Klinikum · Munich, Bavaria · NCT06307262

• Evaluation of the Innoventric Trillium™ Stent Graft for treating severe tricuspid regurgitation

  This study is testing a new stent graft to see if it can help people with severe tricuspid regurgitation feel better.

  Recruiting at 10 sites Innoventric LTD · Thousand Oaks, California and 9 other locations · NCT06212193

• Assessing a new method for replacing the tricuspid valve in patients with severe regurgitation

  This study is testing a new way to replace the tricuspid valve in people with severe heart valve problems to see if it is safe and works well.

  Recruiting at 10 sites Laplace Interventional, Inc · Tucson, Arizona and 9 other locations · NCT06183684

• Global registry of transcatheter tricuspid valve replacement

  This registry will collect information to see how transcatheter tricuspid valve replacement performs and what complications happen in adults with native tricuspid regurgitation.

  Recruiting at 30 sites Montefiore Medical Center · Phoenix, Arizona and 30 other locations · NCT06033274

• Evaluating the DUO System for treating Tricuspid Regurgitation

  This study is testing a new heart valve system to see if it can help people with severe tricuspid regurgitation feel better and improve their heart function.

  Recruiting at 17 sites CroiValve Limited · Phoenix, Arizona and 17 other locations · NCT05913908

• Evaluating the VDyne System for treating severe tricuspid regurgitation

  This study is testing a new heart valve replacement system to see if it can help people with severe tricuspid regurgitation feel better.

  Recruiting at 9 sites VDyne, Inc. · Los Angeles, California and 10 other locations · NCT05848284

• Evaluating a new device for treating tricuspid regurgitation

  This study is testing a new device to see if it can safely help people with moderate to severe tricuspid regurgitation feel better.

  Recruiting at 14 sites VDyne, Inc. · Sydney, New South Wales and 20 other locations · NCT05797519

• Preventing tricuspid regurgitation during pacemaker lead implantation

  This study is testing if using a special ultrasound during pacemaker lead placement can help prevent heart valve problems compared to just using X-rays.

  Recruiting LMU Klinikum · Munich, Bavaria · NCT05667519

• Evaluating the DragonFly-T System for Severe Tricuspid Regurgitation

  This study is testing a new device to see if it can help people with severe tricuspid regurgitation feel better and avoid surgery.

  Recruiting at 2 sites Hangzhou Valgen Medtech Co., Ltd · Chengdu, Sichuan and 1 other locations · NCT05556460

• Registry for outcomes of percutaneous tricuspid valve repair

  This study is testing how well the TriClip™ device works for treating severe tricuspid regurgitation in critically ill patients who still have symptoms despite taking medication.

  Recruiting Helios Klinikum Pforzheim · Pforzheim · NCT05179616

• Follow-up of patients treated with TricValve® for heart valve issues

  This study follows patients who have had treatment for severe tricuspid regurgitation using the TricValve® system to see how well the valve is working over the next five years.

  Recruiting at 12 sites P+F Products + Features GmbH · Sankt Pölten, Lower Austria and 27 other locations · NCT05114850

• Evaluating the Trisol system for treating tricuspid regurgitation

  This study is testing a new device called the Trisol system to see if it can safely help people with moderate to severe tricuspid regurgitation feel better.

  Recruiting at 6 sites Trisol Medical · Los Angeles, California and 6 other locations · NCT04905017

• Follow-up on Abbott annuloplasty devices for heart valve repair

  This study is testing how safe and effective Abbott annuloplasty devices are for repairing heart valves in adults who are having heart surgery.

  Recruiting at 13 sites Abbott Medical Devices · Durham, North Carolina and 16 other locations · NCT04761120

• Monitoring patients with severe tricuspid regurgitation in Hamburg

  This study is looking at patients with serious tricuspid regurgitation to see what factors can help predict their health outcomes and improve treatment options.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT04755842

• Registry for treating severe tricuspid valve issues

  This study looks at how well different treatments work for people with severe tricuspid valve problems who can't have surgery because of high risks.

  Recruiting LMU Klinikum · Munich · NCT04653428

• Registry of right heart interventions in Berlin

  This study looks at how well different treatments for right heart valve problems, like the TriClip and Cardioband, help patients feel better and avoid hospital visits.

  Recruiting Charite University, Berlin, Germany · Berlin · NCT04570163

• Transcatheter valve repair for severe tricuspid regurgitation

  This study is testing a new valve repair system to see if it helps people with severe tricuspid regurgitation feel better compared to just taking their medications.

  Recruiting at 45 sites Edwards Lifesciences · Phoenix, Arizona and 78 other locations · NCT04097145

• Minimally invasive treatment for tricuspid regurgitation

  This study is testing a new device to see if it can safely help people with a leaky heart valve feel better and improve their heart function.

  Recruiting at 3 sites Micro Interventional Devices · Aarhus and 5 other locations · NCT03692598

• Surgical correction of tricuspid valve issues in patients receiving LVADs

  This study is testing whether fixing tricuspid valve problems during the placement of a heart pump can help people with severe heart failure feel better.

  Recruiting University of Washington · Seattle, Washington · NCT02537769

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Right Heart MRI to Predict Outcomes in Functional Tricuspid Regurgitation

  This NIH grant aims to use advanced heart MRI to better predict who with functional tricuspid regurgitation will have worse outcomes or respond to therapies.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11448728

• Right Heart Pressure-Volume Insights to Guide Valve Repair Decisions

  A new funding project is exploring a pressure-volume tool during right-heart catheterization to help doctors decide which patients with severe tricuspid regurgitation will benefit most from transcatheter valve repair.

  NIH research Bridgesource Medical Corporation · Austin, United States · NIH-11407066

Related topics

Quick answers

How many Tricuspid Regurgitation clinical trials are recruiting right now?

37, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 26 countries. The most sites are in Germany (15 trials), United States (11 trials), Canada (4 trials), China (4 trials), Spain (4 trials). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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