MMVD: A Multicenter Registry to Understand Multiple and Mixed Valvular Heart Disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This national, prospective registry collects data from adults diagnosed with MMVD across multiple centers. Participants are followed at 1, 2, 3, 4, and 5 years to document clinical status, imaging results, and treatment approaches. The study aims to describe prevalence, imaging strategies, and management patterns, and to identify prognostic factors for different combinations of valve disease. It does not assign a specific intervention but observes real-world care to improve guidance beyond isolated valve disease recommendations. Enrollment requires echocardiographic confirmation of MMVD and informed consent.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* The patient has been informed of the study and has not refused to participate.
* An echocardiographic diagnosis of MMVD is defined as having at least two moderate to severe valvulopathies, as assessed by a cardiologist using transthoracic echocardiography (TTE), on one or more valves. This is in line with the recommendations of the ESC, the ASE, and expert opinion.

Exclusion Criteria:

* History of valve surgery or percutaneous valve intervention involving the valve in question.
* A history of infective endocarditis, whether treated surgically or not, confirmed according to the modified Duke criteria.
* Acute infective endocarditis at the time of evaluation for inclusion, confirmed according to the modified Duke criteria.
* Complex congenital heart disease.
* Patients who are already included in the European EACVI-MMVD study.
* Pregnant women
* Patients not affiliated to social security
* Patients who are minors
* Patients under guardianship, curatorship or judicial supervision
* Patients who refuse to participate in this register.

Where it's running

• Chu Lille- Hopital Cardiologique
  Lille, France Recruiting
• Chu Lariboisiere (Aphp)
  Paris, France Recruiting

Study contacts

• Study coordinator: Théo PEZEL
• Email: multivalve@sfcardio.fr
• Phone: 01 44 90 70 28

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Hydra THV Transfemoral Valve Implantation in Severe Aortic Stenosis

  This registry tests how safely and effectively the Hydra THV works when implanted through the femoral artery in adults with severe symptomatic aortic stenosis.

  Recruiting at 8 sites Fundación EPIC · Aravaca and 7 other locations · NCT07566624

• Heart sound signals to detect valve and artery disease early

  This observational study tests whether a new digital stethoscope-like device can pick up heart sound patterns to detect valvular or coronary artery disease earlier in people who are already getting heart imaging.

  Recruiting Cambridge University Hospitals NHS Foundation Trust · Cambridge · NCT07496775

• Pulmonary Vascular Disease in Valvular Heart Disease: How Valve Procedures Affect Blood Flow

  This study tests how blood flow in the lungs changes in adults with left-sided valve disease who are having valve surgery and looks to see if patterns can predict reversibility of tricuspid regurgitation and right heart dysfunction.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07483203

• DELINEATE-Prospective: AI-assisted echocardiogram analysis for valve disease

  This project will test whether an AI system can automatically analyze echocardiograms to help doctors detect valve problems in adults who get heart ultrasounds.

  Recruiting Columbia University · New York, New York · NCT07197736

• Aortic valve sizing: comparing CT scan measurements with measurements taken during surgery for people having surgical aortic valve replacement

  This will see if CT scan measurements match the aortic valve sizes surgeons measure during surgical aortic valve replacement in adults with severe aortic stenosis.

  Recruiting Maria Cecilia Hospital · Cotignola, Ravenna · NCT07125469

• Screening for valvular heart disease with a single-lead ECG

  This project will test whether a one-minute single-lead ECG can detect valve problems in adults by comparing ECG recordings to echocardiogram results.

  Recruiting I.M. Sechenov First Moscow State Medical University · Moscow · NCT07099417

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.