Understanding the role of PKD3 in heart valve disease
Official title: PKD3 and Valvular Heart Disease
Funded at University of Rochester · NIH-11135716 · Data updated 2026-11-12
This study is looking into how certain heart cells change and affect heart valve health in people with valvular heart disease, with the hope of finding new ways to treat this condition and help patients feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $581,493 |
| NIH project number | 1R56HL174537-01 |
| Project ID | NIH-11135716 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with valvular heart disease or those at risk for developing this condition.
✕Less likely to help
Patients with non-cardiovascular conditions or those without any heart valve issues may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind valvular heart disease (VHD), which affects a significant number of patients requiring cardiac surgery. It focuses on a biological process called endothelial mesenchymal transition (EndMT), where specific heart cells change their function and characteristics, impacting heart valve formation and health. By studying how certain proteins, particularly PKD3, influence this process, the research aims to uncover new therapeutic strategies for managing and treating VHD. Patients may benefit from improved understanding and potential new treatments derived from these findings.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve the management and treatment of valvular heart disease.
How similar studies have gone: Previous studies have shown promise in understanding the molecular pathways involved in heart valve diseases, indicating that this research builds on established findings.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Jin, Zheng-Gen — University of Rochester
- Study coordinator: Jin, Zheng-Gen
Related research
Other NIH-funded projects on the same topics.
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-
Improving heart valve disease assessment using advanced MRI techniques
This study is testing a new type of heart scan to help doctors better understand and treat mitral valve regurgitation, so if you have this condition, it could lead to more accurate diagnoses and better treatment options for you.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.