Improving heart valve disease diagnosis with stress cardiac MRI
Official title: A comprehensive valvular heart disease assessment with stress cardiac MRI
Funded at Ohio State University · NIH-11138573 · Data updated 2026-11-12
This project aims to create a better way to understand mitral valve problems using a special heart MRI scan, helping doctors decide the best treatment for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 1, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $678,699 |
| NIH project number | 5R01HL151697-05 |
| Project ID | NIH-11138573 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with mitral valve regurgitation who are seeking a more precise understanding of their condition and treatment options would be ideal candidates.
✕Less likely to help
Patients without mitral valve regurgitation or those not requiring advanced imaging for their heart condition would likely not benefit from this specific research.
What this research studies
Many people experience mitral valve regurgitation, a condition where a heart valve doesn't close properly. Currently, diagnosing and deciding when to treat this condition can be challenging with standard tests. Our goal is to develop a new, comprehensive stress cardiac MRI scan that can provide clearer, more detailed information about your heart valve. This advanced imaging could help doctors make more confident decisions about the best time for surgery or other treatments, leading to better outcomes for you.
Why it matters
Potential benefit: If successful, this new MRI method could lead to more accurate diagnoses and more timely, effective treatment plans for individuals with mitral valve regurgitation.
How similar studies have gone: While cardiovascular MRI has shown promise in predicting outcomes for mitral valve patients, this project focuses on developing and validating a novel stress protocol to overcome existing limitations in routine clinical care.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Ahmad, Rizwan — Ohio State University
- Study coordinator: Ahmad, Rizwan
Related research
Other NIH-funded projects on the same topics.
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Understanding how blood vessel cells change to help or worsen heart valves
Researchers are studying how endothelial cells change and contribute to mitral valve prolapse to find better ways to treat this common heart valve condition.
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AI to find early mitral valve problems and predict future heart risks
This project uses artificial intelligence on heart ultrasound images to find early mitral valve changes and predict which adults might later develop serious heart complications.
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Understanding the role of PKD3 in heart valve disease
This study is looking into how certain heart cells change and affect heart valve health in people with valvular heart disease, with the hope of finding new ways to treat this condition and help patients feel better.
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Using AI to improve diagnosis and outcomes for mitral valve disease
This study is looking at how we can use advanced computer technology to better understand mitral valve disease, helping doctors spot early signs of problems in heart images so they can provide better care and treatment for patients like you.
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Understanding Cilia's Role in Heart Valve Disease
This project explores how tiny structures called cilia and certain gene changes might cause common heart valve problems like mitral valve prolapse.
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Improving heart valve disease assessment using advanced MRI techniques
This study is testing a new type of heart scan to help doctors better understand and treat mitral valve regurgitation, so if you have this condition, it could lead to more accurate diagnoses and better treatment options for you.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.