Improving methods to encapsulate insulin-producing cells for treating Type 1 diabetes
Official title: Optimizing encapsulation to treat Type 1 diabetes mellitus: the role of oxygenation, antigen shedding and innate immune response in graft success
Funded at University of Miami School of Medicine · NIH-10543809 · Data updated 2026-11-12
This study is looking at ways to better protect insulin-producing cells for people with Type 1 diabetes, so they can work well after being transplanted, with the hope of creating a more effective treatment for you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | January 15, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $390,726 |
| NIH project number | 5R01DK116875-05 |
| Project ID | NIH-10543809 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Type 1 diabetes who may benefit from new treatment options involving cell transplantation.
✕Less likely to help
Patients with Type 2 diabetes or those who do not have a need for insulin-producing cell therapies may not benefit from this research.
What this research studies
This research focuses on enhancing the encapsulation techniques used to protect insulin-producing cells for patients with Type 1 diabetes. It investigates how factors like oxygen levels, the shedding of antigens, and the body's immune response affect the success of these cell grafts. By optimizing the materials and methods used for encapsulation, the research aims to improve the viability and function of these cells when transplanted into patients. The goal is to create a more effective treatment option that can be translated into clinical practice.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Type 1 diabetes, potentially reducing the need for insulin injections.
How similar studies have gone: Previous research has shown promise in encapsulation techniques for cell therapies, but this specific approach is novel and aims to address existing limitations.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Fraker, Christopher Alan — University of Miami School of Medicine
- Study coordinator: Fraker, Christopher Alan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.