Fully automated artificial pancreas for managing type 1 diabetes
Advanced Artificial Pancreas Systems to Enable Fully Automated Glycemic Control in Type 1 Diabetes Mellitus
A new fully automated insulin delivery system that predicts meals and uses faster-acting insulin to help people with type 1 diabetes keep blood sugar in range.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11159389 on NIH RePORTER |
What this research studies
This project is building a closed-loop artificial pancreas that recognizes meal patterns and gives insulin in advance so you do not have to announce meals or precisely count carbs. The team will combine pattern-recognition algorithms with faster-acting insulin analogs to try to reduce post-meal high blood sugars. They plan two small pilot studies followed by a larger seven-month main study, using data from earlier clinical work to refine the system. Participants will wear a continuous glucose monitor and an insulin pump while researchers tune the algorithm and insulin timing.
Who could benefit from this research
Good fit: People with type 1 diabetes who use or are willing to use an insulin pump and continuous glucose monitor and who can try faster-acting insulin formulations are the best fit.
Not a fit: People without type 1 diabetes, those not on insulin therapy, or those unable to use a pump/CGM or faster-acting insulin are unlikely to benefit from this work.
Why it matters
Potential benefit: If successful, the system could reduce the burden of meal-time diabetes management and lower post-meal high blood sugar for people with type 1 diabetes.
How similar studies have performed: Automated insulin delivery systems have already improved glucose control, but combining meal-predicting algorithms with accelerated insulins is a newer approach with limited prior testing.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Breton, Marc D — University of Virginia
- Study coordinator: Breton, Marc D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.