Using exercise to manage high blood sugar after missed insulin doses
Physical Activity to Prevent and Treat Hyperglycemia From a Mistimed Bolus Insulin Dose: The MISSED DOSE Study
NA · Institut de Recherches Cliniques de Montreal · NCT06686329
This study is testing if brisk walking after missing insulin can help young adults with type 1 diabetes keep their blood sugar levels in check.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 24 Years |
| Sex | All |
| Sponsor | Institut de Recherches Cliniques de Montreal (other) |
| Locations | 1 site (Montreal, Quebec) |
| Trial ID | NCT06686329 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of combining brisk walking with a post-prandial insulin dose on blood glucose levels in individuals with type 1 diabetes who miss their pre-meal insulin. Participants will be monitored using continuous glucose monitors (CGMs) to assess the effectiveness of this approach in preventing hyperglycemia. The study focuses on young adults aged 18-24 years who have been diagnosed with type 1 diabetes for at least two years and have a recent glucose management indicator below 9.9%. By understanding the relationship between exercise and insulin timing, the study aims to provide practical solutions for managing blood sugar levels more effectively.
Who should consider this trial
Good fit: Ideal candidates for this study are young adults aged 18-24 years with type 1 diabetes who have been diagnosed for at least two years and use a Dexcom G7 continuous glucose monitor.
Not a fit: Patients who may not benefit from this study include those with conditions that could make exercise harmful, such as significant renal disease or gastroparesis.
Why it matters
Potential benefit: If successful, this approach could help patients better manage their blood sugar levels after missed insulin doses, potentially reducing the risk of complications associated with hyperglycemia.
How similar studies have performed: While the specific combination of exercise and mistimed insulin dosing is novel, previous studies have shown that physical activity can positively influence blood glucose management in diabetes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18-24 years * Type 1 diabetes diagnostic for at least two years * Estimated glycated hemoglobin or glucose management indicator obtained from the past 30 days of CGM data of \< 9.9% * Use a Dexcom G7 CGM in routine care Exclusion Criteria: * Changes in insulin management strategy within the past 2 months * Diagnosis of gastroparesis * Having a condition that could render exercise harmful * Intolerance to gluten and lactose * Having significant renal disease (e.g., eGRF \< 30 ml/min) * Inability to provide informed consent due to cognitive deficit * Currently taking other medications (other than insulin) that may alter glucose metabolism (e.g., non-insulin antihyperglycemic drugs such as sglt2-inhibitors, corticosteroids), unless dosages thereof have been stable for more than three months * For women, being pregnant or breastfeeding
Where this trial is running
Montreal, Quebec
- Institut de recherches cliniques de Montréal — Montreal, Quebec, Canada (RECRUITING)
Study contacts
- Study coordinator: Corinne Suppère, MSc
- Email: corinne.suppere@ircm.qc.ca
- Phone: 514-987-5597
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Type 1 Diabetes Mellitus, Type 1 diabetes, Exercise, Hyperglycemia