Condition

Type 2 Diabetes Mellitus clinical trials and research

• 42Clinical trials
• 14NIH research projects
• 2New in 30 days
• 36Countries

Newest Type 2 Diabetes Mellitus clinical trials

All recruiting trials (42)

• Ocular Changes in People Using Tirzepatide or Semaglutide

  This study checks whether eye structure and blood vessels change in adults with obesity who are taking semaglutide or tirzepatide as part of routine care.

  Recruiting Istanbul University · Istanbul, Istanbul · NCT07924618

• Acupuncture plus vitamin B12 for diabetic heart nerve damage

  This study tests whether adding acupuncture to standard care and vitamin B12 can help adults with type 2 diabetes who have damaged the nerves that control the heart.

  Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT07907536

• Clinical decision support to help consider SGLT2 inhibitors after AKI in type 2 diabetes

  This pilot test checks if a CDS message given to clinicians can help decide whether to consider SGLT2 inhibitors for adults with type 2 diabetes who recently had acute kidney injury.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07868666

• Body composition changes after starting GLP-1 therapies in adults with obesity or type 2 diabetes

  This study will follow adults with obesity and/or type 2 diabetes who are starting or adjusting a GLP-1 receptor agonist to see how their muscle and fat change over about a year.

  Recruiting at 2 sites Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran · Mexico City, Mexico City and 1 other locations · NCT07835360

• Single-dose PK study of HRS-4729 in adults with and without kidney impairment

  This study tests a single dose of HRS-4729 to see how the body handles it in adults with various levels of kidney function compared with healthy adults.

  Recruiting Phase 1 Fujian Shengdi Pharmaceutical Co., Ltd. · Chengdu, Sichuan · NCT07807059

• Once-daily ASC30 to See if it helps adults with obesity or overweight and Type 2 diabetes

  This study tests three daily doses of ASC30 against placebo in adults who are overweight or obese and have Type 2 diabetes to see if it helps with weight loss and safety over time.

  Recruiting at 6 sites Phase 3 Ascletis Pharma Inc · Birmingham, Alabama and 134 other locations · NCT07743450

• Canagliflozin for Type 2 Diabetes with Mild Cognitive Impairment

  This study tests whether canagliflozin can help people with type 2 diabetes and mild cognitive impairment see if their thinking and memory improve.

  Recruiting Phase 4 Fudan University · Shanghai, Shanghai Municipality · NCT07711171

• Elecoglipron plus background insulin in adults with type 2 diabetes

  This study tests whether adding Elecoglipron to existing insulin therapy helps adults with type 2 diabetes manage their blood sugar better than a placebo.

  Recruiting at 6 sites Phase 3 AstraZeneca · Little Rock, Arkansas and 131 other locations · NCT07664553

• Can Elecoglipron help adults with type 2 diabetes compared with an existing medicine called semaglutide?

  This study tests whether the pill Elecoglipron works as well as oral semaglutide in adults with type 2 diabetes who have added heart risk factors.

  Recruiting at 107 sites Phase 3 AstraZeneca · Birmingham, Alabama and 209 other locations · NCT07662213

• Elecoglipron vs placebo for adults with type 2 diabetes and impaired kidney function on dapagliflozin

  This study tests whether elecoglipron can help adults with type 2 diabetes and kidney impairment who are taking or may take an SGLT2 inhibitor called dapagliflozin, in addition to their other diabetes medicines.

  Recruiting at 19 sites Phase 3 AstraZeneca · Sun City, Arizona and 185 other locations · NCT07662135

• Combination therapy of Elecoglipron and Dapagliflozin in adults with type 2 diabetes

  This trial tests whether the combination of Elecoglipron and Dapagliflozin works better than each drug alone to improve blood sugar control in adults with type 2 diabetes.

  Recruiting at 116 sites Phase 3 AstraZeneca · Huntsville, Alabama and 302 other locations · NCT07662109

• Elecoglipron with or without dapagliflozin in adults with type 2 diabetes

  This study tests whether elecoglipron, alone or with dapagliflozin, helps adults with type 2 diabetes better control blood sugar than a placebo.

  Recruiting at 2 sites Phase 3 AstraZeneca · Birmingham, Alabama and 148 other locations · NCT07662044

• Automated Passive Case-Finding for Advanced Liver Fibrosis in MASLD

  This program automatically screens high‑risk adults aged 50–75 in primary care to see if they have advanced liver fibrosis and possible MASLD, using routine blood tests and reflex lab tests without extra work for clinicians.

  Recruiting Hospital General Universitario Gregorio Marañon · Madrid, Madrid · NCT07658755

• Omnipod 6 vs Omnipod 5: a head-to-head test in kids and adults with type 1 or type 2 diabetes

  This study tests whether the Omnipod 6 system improves blood sugar control compared with the Omnipod 5 in people with type 1 or type 2 diabetes who aren’t at goal.

  Recruiting at 11 sites Insulet Corporation · Los Angeles, California and 10 other locations · NCT07579702

• Finerenone in adults with CKD and type 2 diabetes in Spain: real-world changes in kidney risk score

  This observational study tests how finerenone affects a kidney-risk score in adults with CKD linked to type 2 diabetes who are already taking finerenone in routine care in Spain.

  Recruiting Bayer · Many Locations · NCT07554469

• HM15275 in adults with type 2 diabetes who have not yet reached goal

  This phase 2 trial tests HM15275 or a placebo to see if it helps adults with type 2 diabetes improve blood sugar over 36 weeks.

  Recruiting at 20 sites Phase 2 Hanmi Pharmaceutical Company Limited · Mesa, Arizona and 19 other locations · NCT07527650

• Fully closed loop Omnipod M system in type 2 diabetes

  This trial tests whether the Omnipod M fully closed-loop insulin system works safely and effectively for adults with type 2 diabetes who use insulin, compared with current therapy.

  Recruiting at 26 sites Insulet Corporation · Los Angeles, California and 26 other locations · NCT07521475

• Structured management of adult cardiovascular risk factors in outpatient care

  This project will try a structured clinic approach to managing blood pressure, cholesterol, diabetes, and weight in adults with cardiovascular risk factors to see if it improves risk control and outcomes.

  Recruiting Universidad Católica San Antonio de Murcia · Santiago, Santiago Metropolitan · NCT07447362

• Luseogliflozin (Lusefi) use in adults with type 2 diabetes

  This non-interventional project will try Lusefi (luseogliflozin) in adults with type 2 diabetes to see how well it lowers blood sugar and how well patients tolerate it during routine care.

  Recruiting Servier Russia · Anapa · NCT07433192

• Carotid ultrasound wall texture to identify cardiovascular risk in Type 2 diabetes

  This project will test whether carotid ultrasound measurements, including intima-media thickness and layer-specific wall texture, can help predict 10-year heart risk in adults aged 40–69 with Type 2 diabetes.

  Recruiting Cardenal Herrera University · Elche, Alicante · NCT07373938

• Pilot radiofrequency vapor ablation of the upper intestine for adults with type 2 diabetes

  This pilot tests whether radiofrequency vapor ablation of the proximal intestine can improve blood sugar control in adults with type 2 diabetes who take non-insulin medications.

  Recruiting at 4 sites Aqua Medical, Inc. · Scottsdale, Arizona and 3 other locations · NCT07355270

• Enicepatide for weight management in people with overweight or obesity and type 2 diabetes

  This trial tests whether enicepatide helps adults with overweight or obesity and type 2 diabetes lose weight compared with a placebo.

  Recruiting at 222 sites Phase 3 Hoffmann-La Roche · Guntersville, Alabama and 221 other locations · NCT07351058

• Targeting liver fat with the CMNT intermittent diet for people with type 2 diabetes and fatty liver

  This study will try a CMNT intermittent energy‑restriction diet to see if lowering liver fat helps adults with type 2 diabetes and nonalcoholic fatty liver disease.

  Recruiting at 3 sites State Key Laboratory of Subhealth Intervention Technology · Yichang, Hubei and 2 other locations · NCT07083336

• Evaluating the effects of finerenone on kidney function in patients with Type 2 diabetes and chronic kidney disease

  This study is testing if adding a new kidney medication called finerenone can help people with Type 2 diabetes and chronic kidney disease improve their kidney function over 48 weeks.

  Recruiting Second Affiliated Hospital of Soochow University · Suzhou, Jiangsu · NCT06838416

• Effects of eating dates on hunger and appetite in adults with Type 2 diabetes

  This study tests if eating three Baghdad dates every day can help adults with Type 2 diabetes manage their hunger and appetite better over 12 weeks.

  Recruiting Hacettepe University · Erzurum, Palandöken · NCT06826235

• Assessing Islet Alpha Cell Function in Type 2 Diabetes Patients

  This study is testing if a new diabetes treatment can help improve the function of certain cells in the pancreas for people who have just been diagnosed with type 2 diabetes.

  Recruiting Phase 3 Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu · NCT06825182

• Effect of Olive Pomace Oil on Blood Sugar Levels

  This study is testing if adding olive pomace oil to meals can help people with type 2 diabetes or those at risk manage their blood sugar levels better.

  Recruiting Instituto de Ciencia y Tecnología de Alimentos y Nutrición · Madrid, Madrid · NCT06723886

• Evaluating the Accu-Chek SmartGuide CGM for Diabetes Management

  This study is testing if the Accu-Chek SmartGuide continuous glucose monitor can help adults with Type 1 or insulin-dependent Type 2 diabetes manage their blood sugar levels better than traditional self-monitoring methods.

  Recruiting at 19 sites Hoffmann-La Roche · Gdansk and 19 other locations · NCT06704672

• Low protein diet combined with dapagliflozin for chronic kidney disease in type 2 diabetes patients

  This study is testing if a low protein diet combined with the medication dapagliflozin can help people with type 2 diabetes and chronic kidney disease slow down their kidney problems.

  Recruiting Phase 4 Anemia Working Group Romania · Bucharest · NCT06281899

• Observational study on the use of finerenone for chronic kidney disease and type 2 diabetes

  This study looks at how well finerenone works and how safe it is for people with chronic kidney disease and type 2 diabetes who are already taking it as part of their regular treatment.

  Recruiting Bayer · Many Locations, New Jersey and 3 other locations · NCT06278207

• Investigating how gene mutations affect diabetes susceptibility in patients

  This study is testing how certain gene changes might affect the risk of developing Type 2 Diabetes in newly diagnosed patients compared to healthy individuals.

  Recruiting The Affiliated Hospital of Xuzhou Medical University · Xuzhou · NCT06277466

• Investigating genetic factors affecting diabetes treatment response

  This study is trying to see how genetic differences affect how well the diabetes drug exenatide works for Chinese patients with Type 2 Diabetes.

  Recruiting The Affiliated Hospital of Xuzhou Medical University · Xuzhou, China · NCT06256419

• Evaluating a new combination therapy for high blood pressure and diabetes

  This study is testing a new combination treatment for people with high blood pressure and type 2 diabetes to see if it works better and is safe compared to their current medications.

  Recruiting at 3 sites Phase 3 Boryung Pharmaceutical Co., Ltd · Jakarta, DKI Jakarta and 2 other locations · NCT06220773

• Using imaging to predict weight loss success after bariatric surgery

  This study is testing if looking at CT scans of belly fat can help predict how much weight people will lose and if their type 2 diabetes will improve after bariatric surgery.

  Recruiting China-Japan Friendship Hospital · Beijing · NCT06169033

• Understanding blood sugar control in patients with Left Ventricular Assist Devices

  This study is trying to see if using a continuous glucose monitor gives better information about blood sugar control than traditional blood tests for people with Left Ventricular Assist Devices and type 2 diabetes.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT05933161

• Understanding chronic kidney disease in Sub-Saharan Africa

  This study is trying to understand how common chronic kidney disease is in Sub-Saharan Africa and what factors might be causing it by looking at the health and lifestyle of adults in the Bagamoyo district.

  Recruiting Swiss Tropical & Public Health Institute · Bagamoyo, Pwani Region · NCT05881447

• Understanding Non-Alcoholic Fatty Liver Disease in Saudi Patients with Type 2 Diabetes

  This study looks at how non-alcoholic fatty liver disease affects Saudi adults with type 2 diabetes over 10 years to see how the disease progresses and what factors might make it worse.

  Recruiting King Saud University · Riyadh, Select A State Or Province · NCT05697991

• Effects of Tirzepatide and Insulin Glargine on Diabetes and Brain Function

  This study tests whether the diabetes medications Tirzepatide and Insulin Glargine can improve blood sugar levels and brain function in people with type 2 diabetes.

  Recruiting Phase 4 Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu · NCT05553093

• Understanding how puberty affects kidney health in youth with diabetes

  This study looks at how puberty affects kidney health in teenagers with type 2 diabetes and obesity to see if the changes during this time can harm their kidneys.

  Recruiting at 2 sites Seattle Children's Hospital · Aurora, Colorado and 1 other locations · NCT05008276

• Madalena combination for treating type 2 diabetes

  This trial will test whether the Madalena combination helps adults with type 2 diabetes who haven't reached blood sugar targets while on two medicines.

  Recruiting Phase 3 Ems · Hortolândia, São Paulo · NCT04670666

• National Diabetes Management Program in China

  This study is trying to create a nationwide database to help improve the care and understanding of diabetes in China by collecting health information and samples from patients.

  Recruiting Shanghai Jiao Tong University School of Medicine · Multiple Locations · NCT03811470

• Investigating nutritional and environmental factors in elderly health

  This study is trying to find out how nutrition and the environment affect the health of older people living in Nanshan to help prevent diseases like high blood pressure and diabetes.

  Recruiting Sun Yat-sen University · Shenzhen, Guangdong and 1 other locations · NCT03569735

NIH-funded research (14)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Exploring new muscle chemistry in adults with Type 2 diabetes

  A study will test a new imaging method to measure muscle metabolites in adults with Type 2 diabetes to better understand how the disease affects their muscles.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11454003

• Save with Care: Help with costs to manage type 2 diabetes

  A digital program helps adults with type 2 diabetes on high-deductible plans save money and get better access to care.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11446492

• Predicting obesity-related diabetes and wound healing with math models

  A math-based model is being built to better understand how obesity drives type 2 diabetes and slow wound healing in adults.

  NIH research Rochester Institute of Technology · Rochester, United States · NIH-11377524

• Improving heart- and kidney-protective treatment for people with type 2 diabetes and chronic kidney disease

  This project will help people with type 2 diabetes and chronic kidney disease get proven medicines that protect the heart and kidneys but are often missed.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11303260

• Personalized nutrition guided by continuous glucose monitors for type 2 diabetes

  See whether using continuous glucose monitors to tailor meals helps adults with type 2 diabetes keep blood sugar under better control.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11240325

• Reducing food insecurity for African American adults with diabetes

  This study is looking at how not having enough food affects African American adults with Type 2 diabetes and is testing whether sending them food boxes or giving them food vouchers helps them manage their blood sugar better, or if using both together works best.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11186463

• Understanding how diabetes affects insulin secretion in the body

  This study is looking into why certain hormones that help your body produce insulin don't work as well in people with Type 2 Diabetes, and it hopes to find new ways to improve treatment for those living with the condition.

  NIH research University of California-Irvine · Irvine, United States · NIH-11087709

• Improving brain barrier function in patients with type 2 diabetes

  This study is looking at ways to help improve brain health in adults with type 2 diabetes by checking how well the blood-brain barrier is working and seeing if taking thiamine can make it better, which could help with thinking and mood.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11074062

• Using continuous glucose monitoring to personalize nutrition for better diabetes management

  This study is looking at how personalized meal plans, guided by real-time blood sugar monitoring, can help adults with type 2 diabetes manage their health better over 12 weeks, and it will compare these tailored plans to regular dietary advice to see which works best.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11047306

• Understanding how Type-2 diabetes affects brain plasticity in older adults

  This study is looking at how Type-2 diabetes affects the brain in older adults, especially how it changes the brain's ability to adapt and learn, and it's for older folks with diabetes who want to understand more about their brain health.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11037985

• Improving heart and kidney treatment for patients with diabetes

  This study is looking into why people with type 2 diabetes and chronic kidney disease aren't getting the heart-protecting treatments they need, and it aims to find ways to make sure these important medications are prescribed more often.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11015914

• Creating a mathematical model to understand obesity-related diabetes and wound healing

  This study is looking at how being overweight affects healing for people with type 2 diabetes, and it aims to create a helpful tool to better understand and improve care for those dealing with diabetes and slow-healing wounds.

  NIH research Rochester Institute of Technology · Rochester, United States · NIH-10937272

• Using tailored meals to help people with diabetes and food insecurity

  This study is looking at how providing healthy, ready-to-eat meals can help people with type 2 diabetes who struggle to get enough food, and it also offers tips on managing their diabetes better.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10903741

• How type 2 diabetes affects brain health and dementia risk

  This study is looking at how not managing type 2 diabetes and prediabetes can affect brain health and memory in young adults aged 18 to 45, and it wants to find out if better diabetes management can help keep your mind sharp.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10854563

Related topics

Quick answers

How many Type 2 Diabetes Mellitus clinical trials are recruiting right now?

42, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 36 countries. The most sites are in China (18 trials), United States (15 trials), Germany (7 trials), Japan (7 trials), Turkey (Türkiye) (7 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 10, Phase 4: 3, Phase 2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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