Understanding how RUNX1 contributes to skin fibrosis in systemic sclerosis.
Official title: Deciphering the Mechanism of RUNX1 in Systemic Sclerosis (SSc) Dermal Fibrosis
Funded at Dartmouth College · NIH-11070677 · Data updated 2026-11-12
This study is looking at how a protein called RUNX1 affects skin thickening in people with systemic sclerosis, a condition that causes hardening of the skin, to help find new ways to treat it and improve patients' lives.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | April 29, 2025 |
| Project end | April 28, 2028 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AR084325-01A1 |
| Project ID | NIH-11070677 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with diffuse cutaneous systemic sclerosis who are experiencing skin fibrosis.
✕Less likely to help
Patients with other forms of autoimmune diseases that do not involve skin fibrosis may not benefit from this research.
What this research studies
This research investigates the role of the RUNX1 protein in the development of skin fibrosis associated with systemic sclerosis (SSc), an autoimmune disease. By analyzing gene expression and utilizing advanced techniques like single-cell RNA sequencing and a 3D tissue model, the study aims to uncover how RUNX1 influences the transition of skin cells into fibrotic cells. The goal is to better understand the mechanisms behind SSc and identify potential therapeutic targets for improving patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce skin fibrosis and improve the quality of life for patients with systemic sclerosis.
How similar studies have gone: Previous research has shown promising results in understanding the role of RUNX1 in other fibrotic conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Parvizi, Rezvan — Dartmouth College
- Study coordinator: Parvizi, Rezvan
Related research
Other NIH-funded projects on the same topics.
-
Hypoxia-linked NUDT21 and 3'UTR changes drive fibrosis in systemic sclerosis
A patient-facing study exploring how a gene called NUDT21 and changes in RNA endings may cause skin and lung fibrosis in systemic sclerosis.
-
Understanding and improving treatment for systemic sclerosis vasculopathy
This study is looking at how systemic sclerosis affects blood vessels, especially in the digestive system, to find better ways to monitor and treat patients like you.
-
Using immune cells to treat fibrosis and inflammation in systemic sclerosis
This study is testing a new treatment for systemic sclerosis that uses specially designed immune cells to target and remove harmful cells causing inflammation and scarring, with the hope of making life better for people with this condition.
-
Interface between immune cells and scarring in the eye
This grant looks at how immune cells influence scar formation in the cornea after injury and how this affects vision.
-
How often to treat schistosomiasis to protect the liver
A randomized trial will test different frequencies ofPraziquantel treatment to prevent liver damage in people aged 15–40 with schistosomiasis in Uganda.
-
Metabolic changes in cells that repair blood vessels in the eye lens to prevent scarring
A drug or approach that changes how certain cells that repair blood vessels in the eye work, to prevent scarring behind the retina in age-related macular degeneration patients treated with anti-VEGF therapy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.