Investigating the role of specific proteins in pulmonary hypertension linked to systemic sclerosis.
Sine Oculis Homeobox Homolog 1 and clusterin in Pulmonary Hypertension associated with Systemic Sclerosis
This study is looking at how certain proteins might play a role in causing pulmonary hypertension in African American women with systemic sclerosis, with the goal of finding new ways to help treat this serious condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11142212 on NIH RePORTER |
What this research studies
This research focuses on understanding how the Sine Oculis Homeobox Homolog 1 (SIX1) and clusterin proteins contribute to pulmonary hypertension (PH) in patients with systemic sclerosis (SSc), particularly among African American women. The study aims to explore the mechanisms of vascular remodeling and cell proliferation that lead to PH, a serious condition that can result in the need for lung transplantation. By analyzing tissue samples and cellular responses, the researchers hope to identify new therapeutic targets that could improve treatment outcomes for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American women diagnosed with systemic sclerosis who are experiencing pulmonary hypertension.
Not a fit: Patients without systemic sclerosis or those who do not have pulmonary hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve the management of pulmonary hypertension in patients with systemic sclerosis.
How similar studies have performed: Preliminary results from similar research have shown promise in understanding the role of SIX1 in vascular remodeling, indicating potential for success in this area.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Karmouty-Quintana, Harry — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Karmouty-Quintana, Harry
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.