Investigating the role of specific proteins in pulmonary hypertension linked to systemic sclerosis.

Who could benefit from this research

What this research studies

This research focuses on understanding how the Sine Oculis Homeobox Homolog 1 (SIX1) and clusterin proteins contribute to pulmonary hypertension (PH) in patients with systemic sclerosis (SSc), particularly among African American women. The study aims to explore the mechanisms of vascular remodeling and cell proliferation that lead to PH, a serious condition that can result in the need for lung transplantation. By analyzing tissue samples and cellular responses, the researchers hope to identify new therapeutic targets that could improve treatment outcomes for affected patients.

Why it matters

Where this research is happening

• University of Texas Hlth Sci Ctr Houston
  Houston, United States Active

Researchers

• Principal investigator: Karmouty-Quintana, Harry — University of Texas Hlth Sci Ctr Houston
• Study coordinator: Karmouty-Quintana, Harry

Related research

Other NIH-funded projects on the same topics.

• Detecting early right-heart changes and future lung high blood pressure in systemic sclerosis

  This project uses advanced heart ultrasound and machine learning to spot early right-heart changes that may predict pulmonary hypertension in people with systemic sclerosis.

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• Detecting heart problems early in patients with systemic sclerosis

  This study is looking for better ways to spot pulmonary arterial hypertension (PAH) early in people with systemic sclerosis (SSc) by using new imaging techniques and smart computer tools, so that doctors can help patients sooner and improve their health.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11015054

• Understanding how CD4 T cells fuel schistosomiasis-related lung disease

  A study explores how specific immune cells and inflammatory signals in schistosomiasis may contribute to pulmonary hypertension in people affected by the disease.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11606580

• CD4 T Cells, Schistosoma, and Pulmonary Hypertension: Understanding How Immune Cells Drive Disease

  A human-health focused study uses a mouse model and human samples to explore how immune cells and inflammation may contribute to a lung blood vessel disease linked to schistosomiasis.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11606579

• CD4 T Cells and Schistosoma-Related Pulmonary Hypertension

  A study to understand how specific immune cells behave in a lung complication caused by schistosomiasis, with the goal of finding targets to prevent or treat it.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11606578

• Clinical CT Imaging to identify and subtype pulmonary hypertension in COPD

  A new CT imaging approach aims to help doctors detect and classify pulmonary hypertension in people with COPD.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11583955

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.