Condition

Dermatomyositis clinical trials and research

• 26Clinical trials
• 6NIH research projects
• 19Countries

Newest Dermatomyositis clinical trials

All recruiting trials (26)

• Anti-CD19/BCMA universal CAR-T cell therapy for refractory autoimmune diseases

  This will try anti-CD19/BCMA universal CAR-T cell therapy in adults with refractory rheumatoid arthritis, dermatomyositis, systemic lupus, or systemic sclerosis to see if it is safe and can control their disease.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT07558850

• Emapalumab for MDA5-positive RP-ILD in adults

  This study tests whether emapalumab can help adults with anti-MDA5 positive rapidly progressive interstitial lung disease who have dermatomyositis-related conditions.

  Recruiting Phase 2 University of Miami · Miami, Florida · NCT07486869

• Long-term follow-up after KYV-101 (CAR T) treatment

  This follow-up will test how long KYV-101 CAR T cells persist and record any delayed side effects in people who previously received KYV-101 for autoimmune diseases like lupus nephritis, myasthenia gravis, stiff person syndrome, rheumatoid arthritis, or multiple sclerosis.

  Recruiting Kyverna Therapeutics · Denver, Colorado · NCT07403188

• Tocilizumab treatment for anti-MDA5 positive dermatomyositis in adults

  This study will try giving tocilizumab or a placebo to adults with anti-MDA5 positive dermatomyositis to see if it improves symptoms and breathing.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07377058

• Patient-rooted insights to shape myositis science

  This global project asks people living with myositis (and their care partners) to share experiences and rank research questions so the community can see which issues matter most.

  Recruiting Myositis International Health & Research Collaborative Alliance Foundation · New Orleans, Louisiana · NCT07374107

• Panniculitis linked to dermatomyositis

  This research will see if people with dermatomyositis who develop panniculitis have distinct clinical or tissue (histologic) features compared with panniculitis from other causes.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07345949

• Factors linked to severe dermatomyositis in Caribbean adults

  See if specific clinical, demographic, and ancestral factors are linked to more severe dermatomyositis in adults of Caribbean ancestry living in Guadeloupe.

  Recruiting Centre Hospitalier Universitaire de la Guadeloupe · Pointe-à-Pitre · NCT07265999

• Photoacoustic and ultrasound imaging for dermatomyositis with calcinosis cutis

  This project will try a combined photoacoustic and ultrasound scan to see if it can monitor skin disease activity and treatment response in adults with dermatomyositis who have calcinosis cutis.

  Recruiting Peking Union Medical College Hospital · Beijing · NCT07037472

• Topical ruxolitinib cream to treat stubborn skin symptoms of dermatomyositis

  This will test whether applying 1.5% ruxolitinib cream helps adults with dermatomyositis whose skin symptoms have not improved with other treatments.

  Recruiting Phase 2 The Cleveland Clinic · Cleveland, Ohio · NCT06857240

• Home monitoring for lung disease in patients with rheumatic diseases

  This study is testing if regular home monitoring can help people with lung disease related to rheumatic diseases manage their condition better than just going to the hospital for check-ups.

  Recruiting Oslo University Hospital · Oslo · NCT06732674

• Understanding how dazukibart works in patients with inflammatory muscle diseases

  This study is testing how well the medication dazukibart works for people with inflammatory muscle diseases like dermatomyositis and polymyositis to see if it helps reduce muscle inflammation and improve strength.

  Recruiting at 24 sites Phase 3 Pfizer · Glendale, Arizona and 25 other locations · NCT06698796

• Treatment of Refractory Juvenile Dermatomyositis with CD19 Targeted CAR-T Cells

  This study is testing a new CAR-T cell therapy to see if it can help kids with tough-to-treat juvenile dermatomyositis feel better and improve their health.

  Recruiting Phase 1 Chongqing Precision Biotech Co., Ltd · Hangzhou, Zhejiang · NCT06686524

• Using CAR T-cell therapy to treat severe autoimmune diseases

  This study is testing if a new CAR T-cell therapy can help people with severe autoimmune diseases like lupus and scleroderma feel better.

  Recruiting Phase 1/2 Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Rome, Lazio · NCT06685042

• Injection of sodium thiosulfate for treating calcinosis

  This study is testing if injections of sodium thiosulfate can safely help people with calcinosis related to conditions like systemic sclerosis and dermatomyositis feel better and reduce their symptoms.

  Recruiting Phase 2 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06672822

• Biomarkers that predict how skin-disease treatments will work

  Researchers are testing blood and skin markers to see if they can forecast which patients with inflammatory skin diseases will respond to systemic treatments over a year.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06599411

• Investigating Neutrophil Extracellular Traps in Systemic Sclerosis

  This study is trying to understand how certain immune cells called Neutrophil Extracellular Traps might be linked to the symptoms and complications of Systemic Sclerosis in patients.

  Recruiting CHU de Reims · Reims · NCT06462768

• Using CAR-T cells to treat autoimmune diseases

  This study is testing a new treatment using modified T cells to see if it can help people with autoimmune diseases by targeting and removing harmful B cells.

  Recruiting Phase 1/2 Miltenyi Biomedicine GmbH · Erlangen, Bavaria · NCT06347718

• KYV-101 CAR T therapy for adult dermatomyositis

  This study is testing a new CAR T therapy called KYV-101 to see if it can help adults with dermatomyositis who haven't found relief from regular treatments.

  Recruiting at 2 sites Phase 1 Stanford University · Palo Alto, California and 1 other locations · NCT06298019

• Evaluating CABA-201 for treating active idiopathic inflammatory myopathy

  This study is testing a new cell therapy called CABA-201 to see if it can help people with active idiopathic inflammatory myopathy feel better by reducing muscle inflammation and weakness.

  Recruiting at 35 sites Phase 2/3 Cabaletta Bio · Orange, California and 37 other locations · NCT06154252

• Using baricitinib to treat patients with dermatomyositis

  This study is testing if the medication baricitinib can help people with dermatomyositis improve while reducing their need for steroids.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Paris · NCT04972760

• Registry and biorepository for rheumatic diseases

  This study is collecting samples and health information from adults with rheumatic diseases at Yale clinics to help researchers learn more about these conditions and improve future treatments.

  Recruiting Yale University · New Haven, Connecticut · NCT04402086

• Using nivolumab to treat patients with autoimmune disorders and advanced cancer

  This study is testing if nivolumab can safely help people with autoimmune disorders who also have advanced cancer by looking at how well it works and what side effects it might cause.

  Recruiting at 40 sites Phase 1 National Cancer Institute (NCI) · Birmingham, Alabama and 51 other locations · NCT03816345

• Using sodium thiosulfate injections to treat ectopic calcifications and ossifications

  This study is testing whether sodium thiosulfate injections can help reduce pain and improve life for people with rare conditions that cause unwanted calcium buildup in their bodies.

  Recruiting at 11 sites Phase 2 University Hospital, Limoges · Bordeaux and 10 other locations · NCT03582800

• Evaluating skin symptoms in dermatomyositis patients

  This study is trying to see how skin symptoms affect people with dermatomyositis and how they respond to treatment using a special scoring system.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT02945345

• Investigating environmental factors linked to anti-synthetase syndrome

  This study is trying to see if certain environmental factors, like infections or other triggers, might play a role in causing anti-synthetase syndrome in people with myositis.

  Recruiting at 2 sites National Institutes of Health Clinical Center (CC) · Miami, Florida and 7 other locations · NCT01276470

• Evaluating causes and effects of myositis in adults and children

  This study looks at the causes and effects of myositis in both adults and children to better understand how it affects the immune system and overall health.

  Recruiting at 2 sites National Institutes of Health Clinical Center (CC) · Atlanta, Georgia and 3 other locations · NCT00017914

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding why Dermatomyositis causes worse outcomes in women

  A patient-centered project to understand why women with dermatomyositis, especially Black women, have more severe disease and death, and to build a regional patient registry to guide better care.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11406169

• Personalized Immunomonitoring for Juvenile Dermatomyositis

  A personalized approach to monitoring immune signals in kids with juvenile dermatomyositis to better understand and track their disease.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11384572

• Precision therapies for dermatomyositis using single-cell RNA data and bioinformatics

  A doctor-scientist team at a major hospital plans to find existing drugs that could treat dermatomyositis by analyzing patient cells at the single-cell level and testing promising options in the lab.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11322715

• Identifying targeted treatments for dermatomyositis using advanced genetic analysis

  This study is looking at dermatomyositis, a tough autoimmune condition, to find better and safer treatments by examining blood and skin samples from patients to see how their immune system is affected, and then using that information to repurpose existing medications.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11124607

• Understanding how skin and blood cell signals affect treatment response in children with dermatomyositis

  This study is looking at why some kids with juvenile dermatomyositis don’t get better with usual treatments by checking their skin and blood for clues, so we can find better ways to help them feel better.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11077252

• Using a cannabinoid to relieve itching and inflammation in dermatomyositis

  This study is looking at a new treatment that could help reduce the severe itching and inflammation caused by dermatomyositis, an autoimmune disease, and it's designed for people who are dealing with this condition.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10656390

Related topics

Quick answers

How many Dermatomyositis clinical trials are recruiting right now?

26, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 19 countries. The most sites are in United States (13 trials), China (5 trials), France (5 trials), Germany (2 trials), Italy (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 3, Phase 3: 2, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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