Detecting heart problems early in patients with systemic sclerosis
Official title: Early Detection of Right Ventricular Dysfunction and Emerging Pulmonary Hypertension in Systemic Sclerosis
Funded at Johns Hopkins University · NIH-11015054 · Data updated 2026-11-12
This study is looking for better ways to spot pulmonary arterial hypertension (PAH) early in people with systemic sclerosis (SSc) by using new imaging techniques and smart computer tools, so that doctors can help patients sooner and improve their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $583,050 |
| NIH project number | 5R01HL162851-03 |
| Project ID | NIH-11015054 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with systemic sclerosis who may be at risk for developing pulmonary arterial hypertension.
✕Less likely to help
Patients without systemic sclerosis or those who do not exhibit risk factors for pulmonary arterial hypertension may not benefit from this research.
What this research studies
This research focuses on improving the early detection of pulmonary arterial hypertension (PAH) in patients with systemic sclerosis (SSc), an autoimmune disease. It aims to develop noninvasive imaging techniques and advanced machine-learning algorithms to identify patients at high risk for PAH before it becomes severe. By analyzing heart function through echocardiography, the study seeks to provide better prognostic markers that can guide timely interventions. The goal is to enhance patient outcomes by diagnosing and treating PAH earlier in the disease process.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and improved treatment options for patients with systemic sclerosis, potentially reducing mortality rates associated with pulmonary hypertension.
How similar studies have gone: Previous research has shown promise in using advanced imaging and machine-learning techniques for early detection of similar conditions, indicating a potential for success in this approach.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Mukherjee, Monica — Johns Hopkins University
- Study coordinator: Mukherjee, Monica
Related research
Other NIH-funded projects on the same topics.
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.