Understanding immune cell interactions in systemic sclerosis
Discovering immune drivers of fibroblast polarization andrecovery in systemic sclerosis
This study is looking at how immune cells and skin cells work together in people with systemic sclerosis to find out what causes skin thickening, with the hope of creating better, personalized treatments to help improve your health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project ID | NIH-11002666 on NIH RePORTER |
What this research studies
This research investigates how immune cells interact with fibroblasts in the skin of patients with systemic sclerosis, a serious autoimmune disease. The study aims to identify specific immune drivers that influence the behavior of fibroblasts, which are responsible for excessive collagen production and fibrosis. By analyzing biological samples and clinical data, the research seeks to develop reliable tools that can help tailor treatments for individual patients based on their unique disease characteristics. The ultimate goal is to improve patient outcomes by better understanding the phases of the disease and how they respond to treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic sclerosis, particularly those experiencing skin and organ fibrosis.
Not a fit: Patients with other autoimmune diseases or those not diagnosed with systemic sclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatment strategies for patients with systemic sclerosis.
How similar studies have performed: Preliminary data suggests that similar approaches have shown promise in understanding fibroblast behavior in systemic sclerosis, indicating potential for success in this research.
Where this research is happening
New York, UNITED STATES
- Hospital for Special Surgery — New York, United States (Active)
Researchers
- Principal investigator: Lakin, Kimberly Showalter — Hospital for Special Surgery
- Study coordinator: Lakin, Kimberly Showalter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.