Condition

SARS CoV 2 Infection clinical trials and research

• 14Clinical trials
• 91NIH research projects
• 32Countries

Newest SARS CoV 2 Infection clinical trials

All recruiting trials (14)

• Cardiovascular health five years after MIS-C in children

  This study tests whether kids who had MIS-C still show cardiovascular differences five years later compared with healthy peers.

  Recruiting Medical University of Warsaw · Warsaw, Masovian Voivodeship · NCT07659847

• Remdesivir to prevent severe COVID-19 in kidney transplant patients

  This study will try giving remdesivir around the time of transplant to see if it prevents severe COVID-19 in adults receiving a kidney transplant who are currently SARS‑CoV‑2 positive with no or mild symptoms.

  Recruiting Phase 2 Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia · Badalona, Barcelona · NCT07197164

• 2-HOBA to reduce persistent immune activation in Long COVID with POTS

  This trial will test whether 2‑HOBA, a compound that scavenges harmful IsoLG-adducts, can reduce immune activation in adults with Long COVID who have POTS.

  Recruiting Phase 2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT07189936

• TFH-targeting COVID-19 booster vaccines with and without the 's3' component

  This trial will test two experimental COVID-19 booster vaccines — one with an added 's3' component and one without — in healthy adults 40–64 to see if 's3' makes immune responses bigger, broader, and longer-lasting and to check safety.

  Recruiting at 2 sites Phase 1/2 University of California, Los Angeles · Los Angeles, California and 1 other locations · NCT06810934

• Evaluating Baricitinib for Long COVID Symptoms

  This study is testing if the medication baricitinib can help adults with Long COVID feel better physically and mentally compared to a placebo.

  Recruiting at 17 sites Phase 3 Vanderbilt University Medical Center · Tucson, Arizona and 16 other locations · NCT06631287

• Study on influenza and COVID-19 effects in pregnant women in India

  This study is testing how getting both COVID-19 and influenza affects pregnant women and their babies, while also looking at how vaccinations might help reduce risks during pregnancy.

  Recruiting at 2 sites Boston University · Boston, Massachusetts and 1 other locations · NCT06168019

• Testing a new method to detect COVID-19 using exhaled air

  This study is testing a new breath test for COVID-19 to see if it works as well as the traditional nose swab method, especially for people showing symptoms or who have been around someone infected.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes and 1 other locations · NCT06099795

• Understanding COVID-19 transmission and health impacts in Malawi

  This study is trying to understand why COVID-19 seems to affect people in Malawi less severely by looking at factors like immune responses and other health conditions in those who have the virus and their close contacts.

  Recruiting Boston University · Boston, Massachusetts and 1 other locations · NCT05973084

• Transcranial Direct Current Stimulation for Long COVID with Headaches and Chronic Pain

  This study tests whether applying mild brain stimulation (tDCS) can help people with long COVID who have headaches, migraines, and ongoing pain.

  Recruiting at 2 sites Fundación Universidad Católica de Valencia San Vicente Mártir · Paiporta, Valencia and 1 other locations · NCT05780450

• Olfactory training for smell issues after COVID-19

  This study is testing if a special smell training program can help people who have trouble smelling after having COVID-19 feel better and improve their sense of smell.

  Recruiting Université du Québec à Trois-Rivières · Trois-Rivières, Quebec · NCT05384561

• Exploring the effects of exercise on children's health with chronic diseases

  This study is testing how exercise can improve the health of children with chronic diseases like cystic fibrosis and sickle cell disease to find safe ways for them to be active.

  Recruiting University of California, Irvine · Irvine, California · NCT05359991

• T cell therapy to prevent COVID-19 in immunocompromised patients

  This study is testing if a new T cell therapy can help prevent COVID-19 in immunocompromised patients who have had a stem cell transplant.

  Recruiting at 2 sites Phase 1 Children's National Research Institute · Washington D.C., District of Columbia and 1 other locations · NCT05141058

• Understanding COVID-19 in kidney transplant recipients in Brazil

  This study looks at how COVID-19 affects kidney transplant patients in Brazil to see what challenges they face and what happens to them after getting the virus.

  Recruiting Hospital do Rim e Hipertensão · São Paulo, Aão Paulo · NCT04494776

• Evaluating treatments for severe community-acquired pneumonia in ICU patients

  This study tests different treatment options for ICU patients with severe pneumonia to see which ones work best, including special strategies for those with COVID-19.

  Recruiting at 234 sites Phase 3 UMC Utrecht · Jacksonville, Florida and 407 other locations · NCT02735707

NIH-funded research (newest 40 of 91)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How COVID-19 infection and genes may influence memory and dementia risk

  This study looks at how getting COVID-19 and a person’s genes together affect the chance of developing memory problems and Alzheimer’s disease later in life.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11617103

• Alzheimer’s-related dementia after COVID-19: how SARS-CoV-2 affects the brain and potential drug repurposing

  This research looks at how COVID-19 may contribute to dementia by studying brain inflammation, blood vessel injury, and virus-host interactions, with the goal of finding existing drugs that could help.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11457086

• IL-22’s role in SARS-CoV-2 infection and tissue protection

  A short study to understand how the cytokine IL-22 might help protect tissues during and after COVID-19 infection, especially in people with complications related to acute graft-versus-host disease.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11451891

• Maternal SARS-CoV-2 infection and its effects on placenta and child development

  This grant studies how COVID-19 infection during pregnancy might change the placenta and influence a child’s brain development, especially in kids who may be at higher genetic risk for ADHD/ASD.

  NIH research Lieber Institute, INC. · Baltimore, United States · NIH-11402254

• How COVID-19 and genetics influence memory and dementia risk in older adults

  This project studies how getting COVID-19 interacts with people’s genetic makeup to affect the likelihood of cognitive decline and Alzheimer’s disease in older adults from diverse backgrounds.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11401787

• Impact of COVID-19 on latent TB reactivation in Kenya

  This project in Kenya checks how having had COVID-19 might influence the reactivation of latent tuberculosis in adults.

  NIH research Mount Kenya University · Thika, Kenya · NIH-11392293

• How COVID-19 and genetic differences may affect memory and Alzheimer's risk across diverse populations

  This project will find out whether having COVID-19 together with certain genetic differences raises the chance of memory loss and Alzheimer's disease in older adults from varied ancestral backgrounds.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11389642

• How COVID-19 and genes may affect memory and Alzheimer's risk in diverse communities

  This project looks at whether COVID-19 infection together with genetic differences raises the chance of memory loss and Alzheimer's disease in older adults from diverse ancestries.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11389638

• Blood DNA markings linked to long COVID symptoms

  This project looks at how patterns of DNA methylation in blood relate to long-term COVID-19 effects in patients who were seriously ill.

  NIH research Albany Medical College · Albany, United States · NIH-11381710

• Brain changes after COVID-19 in older adults and how they affect memory and thinking

  This project looks at how COVID-19 may affect brain health and thinking in older adults over time.

  NIH research University of Rochester · Rochester, United States · NIH-11377463

• Impact of SARS-CoV-2 on kids with and without asthma

  This grant study looks at how SARS-CoV-2 affects the immune response to respiratory viruses in children, including those with asthma.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11376056

• IBS after COVID-19: how SARS-CoV-2 infection may lead to irritable bowel syndrome

  This project explores whether people who had SARS-CoV-2 infection may develop IBS and what factors raise that risk.

  NIH research University of Arizona · Tucson, United States · NIH-11375083

• SARS-CoV-2, APOE, and dementia: how COVID-19 affects thinking in aging and Alzheimer’s

  This NIH grant explores how COVID-19 may impact brain function and pathology in people with aging or Alzheimer's disease, including how APOE genes might influence the effects.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11370014

• A new approach to block SARS-CoV-2 by turning its own replication against it

  A novel intranasal therapy uses a virus-activated toxin strategy to kill infected cells while sparing healthy ones, aiming to reduce COVID-19 infection in a mouse model.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-11361615

• Immune responses to malaria, HIV, and COVID-19 vaccines in diverse populations

  A large NIH effort is studying how our immune system reacts to HIV, malaria, and COVID-19 vaccines to help design better vaccines for everyone.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11361542

• Long-term health effects for moms and babies after COVID during pregnancy

  This grant study follows pregnant people and their children to understand long-term health effects after SARS-CoV-2 infection during pregnancy.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11361138

• Impact of prenatal SARS-CoV-2 exposure and vaccination on a child’s behavior, thinking, and brain function

  A study following children up to age 3 to understand how being exposed to COVID-19 before birth and maternal vaccination during pregnancy might affect behavior, thinking skills, and brain function.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11345368

• How the nose's support cells respond to COVID-19 and cause loss of smell

  Researchers are looking at how support cells in the nose react to COVID-19 to help explain sudden loss of smell in people who get the virus.

  NIH research University of California at Davis · Davis, United States · NIH-11308714

• Alzheimer’s-related markers after COVID-19

  This project will measure Alzheimer’s-related blood and brain markers in people aged 60 and older who had COVID-19 and are experiencing new memory or thinking problems.

  NIH research New York University School of Medicine · New York, United States · NIH-11302669

• Understanding the long-term effects of COVID-19

  This study is looking at the long-term health effects that people who have recovered from COVID-19 might experience, and it's for anyone who has had the virus and wants to help researchers understand lingering symptoms better by sharing their health information and samples.

  NIH research New York University School of Medicine · New York, United States · NIH-11301210

• Understanding COVID-19's Effects on Brain Health in Aging and Alzheimer's Disease

  This project looks at how COVID-19 affects thinking and brain health over time, especially in older adults and those with a gene linked to Alzheimer's.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11297471

• How lung memory T cells protect you after COVID-19 infection or vaccination

  Researchers want to see if immune cells that stay in the lungs after COVID-19 infection or vaccination help protect people from future severe lung illness.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-11291808

• Role of ACE2 in Maternal SARS-CoV-2 Infection and Offspring Lung Health

  A study at Johns Hopkins will look at how a mother’s COVID-19 infection might affect a child’s lung health later on, using a humanized ACE2 mouse model to explore inflammatory risks.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11273633

• How COVID-19 causes blood clots and tiny microclots

  This work looks at why people with COVID-19 develop blood clots and tiny microclots that may lead to lasting tissue damage.

  NIH research University of Kentucky · Lexington, United States · NIH-11258033

• How COVID can change brain circuits and cause long-term brain symptoms

  This project looks at brain circuit changes in people with long COVID who have cognitive problems, mood or sleep changes, dizziness, or autonomic symptoms.

  NIH research Yale University · New Haven, United States · NIH-11238500

• Repairing brain blood-vessel signaling to fix COVID-related blood–brain barrier damage

  This work tests whether restoring a key signaling pathway in brain blood vessels can heal the blood–brain barrier and help with long-term brain problems after COVID-19.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11238015

• How the protein SAMHD1 changes the immune response to COVID-19

  This project looks at how a protein called SAMHD1 alters immune reactions in lung and immune cells during SARS‑CoV‑2 infection to better understand COVID‑19, especially in older adults.

  NIH research University of Iowa · Iowa City, United States · NIH-11230255

• How COVID-19 and genetics may affect memory and Alzheimer’s risk in diverse older adults

  The team will compare memory tests, brain scans, blood markers, and genes in older adults with and without COVID-19 to learn how infection and genetic differences relate to later memory loss and Alzheimer's risk.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11180186

• How COVID-19 during pregnancy might affect the placenta and your baby's early brain development

  This project looks at whether having COVID-19 while pregnant changes the placenta and raises the chance of developmental problems in babies, especially for boys and those with genetic risk.

  NIH research Lieber Institute, INC. · Baltimore, United States · NIH-11179191

• Investigating how SARS-CoV-2 affects the brain and immune system

  This study is looking at how the COVID-19 virus affects the brain and nervous system, especially why some people experience symptoms like headaches, seizures, or loss of smell and taste, and it invites patients to help by sharing their experiences and samples.

  NIH research Yale University · New Haven, United States · NIH-11175753

• How young children's immune systems respond to COVID-19

  Looking at antibody and inflammation responses after COVID-19 in children and some adults to better understand why children often have milder illness.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11173627

• Long-term COVID effects in the Cherokee Nation

  This project looks for lasting health problems after COVID-19 among American Indian people who live in the Cherokee Nation.

  NIH research Cherokee Nation · Tahlequah, United States · NIH-11163416

• How lung cancer affects immune responses to COVID-19

  This study is looking at how people with lung cancer react to COVID-19 infections and vaccines, checking how well their immune systems work and what that means for their health over time.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11160900

• Understanding how COVID-19 during pregnancy affects infant brain development

  This study is looking at how a mother's COVID-19 infection during pregnancy might affect her baby's brain development and health as they grow, so we can better understand any risks and help families in the future.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11139564

• Effects of COVID-19 on pregnancy and maternal health outcomes

  This study is looking at how COVID-19 and its effects on health might impact pregnancy and the health of mothers and babies, especially for those facing challenges in healthcare, to help improve outcomes for everyone during and after pregnancy.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11136605

• How a Lung Protein Affects Asthma and COVID-19

  This project explores how a natural lung protein called SP-A might protect people with type 2 asthma from severe COVID-19 by influencing immune responses.

  NIH research University of Arizona · Tucson, United States · NIH-11132932

• Understanding long-term health effects of COVID-19 during pregnancy on mothers and children

  This project looks at how COVID-19 infection during pregnancy might affect the long-term health of mothers and their children.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11129770

• Brain changes from COVID-19 and long-term memory in older adults

  This project looks at how COVID-19 affects the brain and memory over time in older adults.

  NIH research University of Rochester · Rochester, United States · NIH-11126660

• Understanding how COVID-19 affects children's immune systems, especially those with asthma

  This research looks at how COVID-19 infection changes how children, both with and without asthma, respond to other common respiratory viruses and future vaccines.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11125785

• Blood DNA methylation markers for long COVID (PASC)

  Researchers are looking for lasting chemical changes in blood DNA that might explain ongoing symptoms in people who had COVID-19.

  NIH research Albany Medical College · Albany, United States · NIH-11123263

Related topics

Quick answers

How many SARS CoV 2 Infection clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 32 countries. The most sites are in United States (8 trials), Spain (3 trials), Canada (2 trials), France (2 trials), India (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 2: 2, Phase 1: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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