Immune responses to malaria, HIV, and COVID-19 vaccines in diverse populations
Official title: Immune Responses to Malaria, HIV and SARS-CoV-2 Infection and Immunization
Funded at Seattle Children's Hospital · NIH-11361542 · Data updated 2026-11-12
A large NIH effort is studying how our immune system reacts to HIV, malaria, and COVID-19 vaccines to help design better vaccines for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | July 19, 2017 |
| Project end | April 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $2,100,000 |
| NIH project number | 5U19AI128914-11 |
| Project ID | NIH-11361542 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals affected by HIV/AIDS, malaria, or COVID-19, and diverse populations who may contribute samples or participate in related studies.
✕Less likely to help
People who do not have exposure to these infections or who are not eligible for related studies may not directly benefit.
What this research studies
This project looks at how people’s immune systems respond to infections and vaccines for three major diseases: HIV/AIDS, malaria, and COVID-19. Researchers will profile different immune responses across diverse populations to identify patterns linked to protection after vaccination or infection. The work involves complex biological analyses and collaboration across experts to connect immune profiles with vaccine efficacy. The goal is to uncover insights that can guide more effective vaccines and therapies for these diseases.
Why it matters
Potential benefit: If successful, findings could inform the design of more protective vaccines and therapies for HIV, malaria, and COVID-19, benefiting patients worldwide.
How similar studies have gone: Prior work has shown that identifying immune signatures can correlate with vaccine protection, supporting the potential for impactful discoveries.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Stuart, Kenneth D — Seattle Children's Hospital
- Study coordinator: Stuart, Kenneth D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.