Understanding how COVID-19 affects children's immune systems, especially those with asthma
Impact of SARS-CoV-2 infection on respiratory viral immune responses in children with and without asthma
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11125785
This research looks at how COVID-19 infection changes how children, both with and without asthma, respond to other common respiratory viruses and future vaccines.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11125785 on ClinicalTrials.gov |
What this research studies
We want to understand why children often have milder COVID-19 symptoms, even those with asthma, which is a common breathing condition. Our team is studying how a past COVID-19 infection might change a child's immune system, affecting how they react to other viruses and upcoming COVID-19 vaccines. We are also exploring if a specific genetic difference in children with asthma might protect them from severe COVID-19. This work uses information from a group of children with asthma in New York City who have been followed since the start of the pandemic.
Who could benefit from this research
Good fit: Ideal candidates for this type of research would be children between 0-11 years old, both with and without asthma, particularly those who have experienced SARS-CoV-2 infection.
Not a fit: Adults or individuals without respiratory conditions like asthma would likely not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could help us better protect children with asthma from respiratory infections and improve vaccine strategies for all children.
How similar studies have performed: This research builds upon existing knowledge of asthma's link to viral infections and utilizes an established pediatric asthma cohort, suggesting a foundation in prior work.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WORGALL, STEFAN — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: WORGALL, STEFAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.