Condition

Cluster Headache clinical trials and research

• 10Clinical trials
• 10Countries

Newest Cluster Headache clinical trials

All recruiting trials (10)

• A real-world look at trigeminal autonomic cephalalgias in Italy

  This study follows adults with TACs like cluster headache and related conditions in routine care to see how treatments work and what factors influence outcomes over time.

  Recruiting Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Milan, MI · NCT07812740

• Magnesium sulfate for acute non-traumatic headache in the ED: 2 g vs 4 g vs standard paracetamol

  This study tests whether intravenous magnesium sulfate given in different doses helps adults with acute non-traumatic headache in the emergency department, compared with paracetamol.

  Recruiting University of Monastir · Monastir · NCT07779486

• Using light therapy to treat chronic cluster headaches

  This study is testing whether light therapy using a special device can help people with chronic cluster headaches feel better.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille and 1 other locations · NCT06540651

• Noninvasive vagus nerve stimulation for prevention and treatment of primary headaches in children and teens

  We will try a noninvasive ear-based vagus nerve stimulator to treat sudden primary headache attacks in children and adolescents aged 7–20.

  Recruiting Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT06277063

• Transcranial Direct Current Stimulation for Long COVID with Headaches and Chronic Pain

  This study tests whether applying mild brain stimulation (tDCS) can help people with long COVID who have headaches, migraines, and ongoing pain.

  Recruiting at 2 sites Fundación Universidad Católica de Valencia San Vicente Mártir · Paiporta, Valencia and 1 other locations · NCT05780450

• Repeated GON injections for chronic cluster headache relief

  This study is testing if repeated injections in the back of the head can help people with chronic cluster headaches have fewer headache attacks.

  Recruiting at 2 sites Phase 3 Leiden University Medical Center · Leiden and 1 other locations · NCT05324748

• Registry for headache and vertigo conditions in China

  This study is collecting information from people of all ages who have headaches or vertigo to see how different treatments work and how these conditions relate to other health issues.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT04939922

• Endoscopic injection of Exparel for craniofacial pain relief

  This study is testing if an injection of Exparel can help people with craniofacial pain, like migraines and cluster headaches, feel better compared to a placebo.

  Recruiting Phase 2 Stanford University · Stanford, California · NCT04930887

• Using Botox to treat chronic cluster headaches

  This study is testing if Botox can help people with chronic cluster headaches who haven't found relief from other treatments.

  Recruiting at 5 sites Phase 3 Norwegian University of Science and Technology · Hamburg and 4 other locations · NCT03944876

• Observational study on cluster headaches and trigeminal neuralgia

  This study is trying to learn more about cluster headaches and trigeminal neuralgia by gathering information from patients to help match them for future treatments.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT02910323

Related topics

Quick answers

How many Cluster Headache clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in China (2 trials), United States (2 trials), Spain (2 trials), Italy (2 trials), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →