Impact of SARS-CoV-2 on kids with and without asthma
Official title: Impact of SARS-CoV-2 infection on respiratory viral immune responses in children with and without asthma
Funded at Weill Medical Coll of Cornell Univ · NIH-11376056 · Data updated 2026-11-12
This grant study looks at how SARS-CoV-2 affects the immune response to respiratory viruses in children, including those with asthma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $765,657 |
| NIH project number | 5R01AI173504-04 |
| Project ID | NIH-11376056 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children 0–11 years old, with and without asthma, who are part of the NYC pediatric asthma cohort or who have data/samples from it.
✕Less likely to help
Children outside the 0–11 age range or not part of the asthma cohort may not directly benefit.
What this research studies
The project follows children aged 0–11 (with and without asthma) to understand how COVID-19 infection changes their immune responses to other respiratory viruses and to the upcoming vaccines. It will use genomic and epigenetic tools to explore genetic factors that may influence outcomes, including a focus on sphingolipid-related variants. The research is based on a pediatric asthma cohort in New York City and will examine respiratory outcomes over time after infection or vaccination. Results could help tailor future care and prevention strategies for children facing COVID-19 and other viral infections.
Why it matters
Potential benefit: If successful, it could inform personalized care for children with asthma during viral infections and guide vaccine strategies.
How similar studies have gone: Other studies have linked viral infections, asthma, and immune responses, but this project adds a genetic/epigenetic angle in a pediatric population.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Worgall, Stefan — Weill Medical Coll of Cornell Univ
- Study coordinator: Worgall, Stefan
Related research
Other NIH-funded projects on the same topics.
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How a Lung Protein Affects Asthma and COVID-19
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Understanding how COVID-19 affects children's immune systems, especially those with asthma
This research looks at how COVID-19 infection changes how children, both with and without asthma, respond to other common respiratory viruses and future vaccines.
-
How SARS-CoV-2 infection affects immune responses in children with and without asthma
This study is looking at how COVID-19 affects the immune systems of children with asthma, especially how their genes might play a role in how they respond to the virus and vaccines, to help find better ways to keep them healthy.
-
How COVID-19 infection and genes may influence memory and dementia risk
This study looks at how getting COVID-19 and a person’s genes together affect the chance of developing memory problems and Alzheimer’s disease later in life.
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This research looks at how COVID-19 may contribute to dementia by studying brain inflammation, blood vessel injury, and virus-host interactions, with the goal of finding existing drugs that could help.
-
IL-22’s role in SARS-CoV-2 infection and tissue protection
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.