Condition

Community-acquired Pneumonia clinical trials and research

• 20Clinical trials
• 14NIH research projects
• 41Countries

Newest Community-acquired Pneumonia clinical trials

All recruiting trials (20)

• How frailty affects outcomes in older people with pneumonia in the ER

  This study will test whether a quick bedside frailty score (the Clinical Frailty Scale) can help predict short-term death and serious complications in people aged 65 and older who come to the emergency department with pneumonia.

  Recruiting Ege University · Izmir, Bornova · NCT07442656

• Fever clinic tracking of acute respiratory infections

  This project follows adults who come to a fever clinic with respiratory infections to see how their symptoms, test results, and outcomes change over time.

  Recruiting Fudan University · Shanghai, Shanghai Municipality · NCT07278700

• Azithromycin versus doxycycline as atypical coverage for adults hospitalized with community-acquired pneumonia on a beta-lactam

  This trial will test whether adding azithromycin or doxycycline to a beta-lactam works better and is safer for adults hospitalized with community-acquired pneumonia.

  Recruiting Phase 4 Mayo Clinic · Scottsdale, Arizona and 4 other locations · NCT07164131

• Noninvasive breathing support for severe community-acquired pneumonia

  This trial tests whether high-velocity nasal insufflation (HVNI) or standard noninvasive ventilation (NIV) better helps adults with community-acquired pneumonia and low oxygen levels avoid intubation or death within 48 hours.

  Recruiting Assiut University · Asyut, Assuit · NCT06996834

• Antibiotic strategies for young children with pneumonia in outpatient care

  This trial will see if a 'watch-and-wait' Safety Net Antibiotic Prescribing (SNAP) approach can safely reduce antibiotic use compared with immediate antibiotics in children aged 12 months to under 6 years with mild community-acquired pneumonia.

  Recruiting at 4 sites Ann & Robert H Lurie Children's Hospital of Chicago · Atlanta, Georgia and 3 other locations · NCT06986148

• Awake prone positioning for adults with community-acquired pneumonia on high-flow nasal oxygen.

  This trial will test whether asking adults with community-acquired pneumonia who are on high-flow nasal oxygen to lie on their stomach while awake can reduce the need for a breathing tube.

  Recruiting at 11 sites University Hospital, Tours · Amiens and 37 other locations · NCT06966310

• Evaluating SR1375 for treating community-acquired pneumonia in adults

  This study is testing a new medication called SR1375 to see if it helps adults in the hospital with community-acquired pneumonia feel better and recover safely.

  Recruiting at 27 sites Phase 2 Shanghai SIMR Biotechnology Co., Ltd. · Fuyang, Anhui and 28 other locations · NCT06577558

• Using clarithromycin to prevent sepsis in pneumonia patients

  This study is testing if adding clarithromycin to the treatment of pneumonia can help prevent sepsis in patients who are at risk.

  Recruiting at 23 sites Phase 3 Hellenic Institute for the Study of Sepsis · Athens, Athens and 23 other locations · NCT06294600

• Comparing Amoxicillin and Amoxicillin/Clavulanate for Pneumonia in Older Adults

  This study is testing whether amoxicillin works just as well as a combination of amoxicillin and clavulanate for treating pneumonia in older adults who are hospitalized.

  Recruiting at 19 sites Phase 3 Nantes University Hospital · Saint-Nazaire, France and 18 other locations · NCT06229288

• Using acyclovir to treat pneumonia in ventilated patients with herpes simplex virus

  This study is testing if giving acyclovir to ICU patients on ventilators who have pneumonia and herpes simplex virus can help them survive better than those who don't receive the medication.

  Recruiting at 28 sites Phase 3 Jena University Hospital · Freiburg im Breisgau, Baden-Wurttemberg and 27 other locations · NCT06134492

• Improving care for children with pneumonia using new diagnostic tools

  This study is testing a new test to see if it can help doctors better treat children with pneumonia by identifying those who don’t need antibiotics, so they can avoid giving unnecessary medication.

  Recruiting McMaster University · Hamilton, Ontario · NCT06114888

• Comparing two flu vaccines for older adults

  This study is testing which of two flu vaccines works better for adults aged 65 and older to prevent the flu and related health issues.

  Recruiting Kaiser Permanente · Oakland, California · NCT06029933

• Customized antibiotic treatment duration for hospitalized pneumonia patients

  This study tests if giving hospitalized pneumonia patients antibiotics for a shorter, personalized time based on their recovery is just as effective as the usual longer treatment.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Garches · NCT05903352

• Using heparin to improve outcomes in patients with community-acquired pneumonia

  This study is testing whether giving heparin to patients with community-acquired pneumonia can help them avoid complications and recover better than standard care.

  Recruiting at 53 sites Phase 3 University of Manitoba · Chicago, Illinois and 67 other locations · NCT05848713

• Evaluating trimodulin for severe community-acquired pneumonia

  This study is testing if adding trimodulin to standard treatment can help adults with severe pneumonia who need breathing support feel better and recover faster.

  Recruiting at 73 sites Phase 3 Biotest · Mobile, Alabama and 169 other locations · NCT05722938

• Evaluating the prevalence of pneumonia-causing bacteria using a urine test

  This study is testing a urine test to see how common pneumonia-causing bacteria are in hospitalized patients with community-acquired pneumonia.

  Recruiting Chinese University of Hong Kong · Shatin · NCT04647630

• Exploring risk factors for poor outcomes in pneumonia patients

  This study looks at what factors might lead to worse recovery in adults with pneumonia to help improve their treatment and outcomes.

  Recruiting Nordsjaellands Hospital · Hillerød · NCT03795662

• Twice daily amoxicillin treatment for children with non-severe pneumonia

  This study is testing if giving children with mild pneumonia amoxicillin twice a day works just as well as giving it three times a day.

  Recruiting Phase 2/3 St. Justine's Hospital · Montreal, Quebec · NCT03031210

• Evaluating treatments for severe community-acquired pneumonia in ICU patients

  This study tests different treatment options for ICU patients with severe pneumonia to see which ones work best, including special strategies for those with COVID-19.

  Recruiting at 234 sites Phase 3 UMC Utrecht · Jacksonville, Florida and 407 other locations · NCT02735707

• Community-acquired pneumonia in adults: who is at risk?

  This project collects clinical data and biological samples from adults with community-acquired pneumonia to see which risk factors, causes, and outcomes are linked to the illness.

  Recruiting Capnetz Stiftung · Hanover · NCT02139163

NIH-funded research (14)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Azithromycin vs doxycycline with beta-lactam in hospitalized adults with pneumonia

  In hospitalized adults with community-acquired pneumonia, this study will compare two antibiotic combinations to see which works better and is safer.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11451639

• Combined immunomodulatory effect of macrolides and corticosteroids in hospitalized CAP patients

  This study looks at whether adding macrolide antibiotics to steroids helps or harms people hospitalized with community-acquired pneumonia (CAP).

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11437358

• Blocking ANGPTL4 to help people with severe community-acquired pneumonia

  This project will test whether blocking the blood protein ANGPTL4 helps adults hospitalized with severe community-acquired pneumonia recover faster and survive more often.

  NIH research University of Washington · Seattle, United States · NIH-11312617

• Pediatric pneumonia severity score (PedCAPS)

  This project will create and check a simple score to predict how serious pneumonia will be in children who come to the emergency room.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11292391

• Ketogenic diet to help muscle in older adults with pneumonia

  A small trial will test if a short 10-day ketogenic (low carb, high fat) feeding helps preserve muscle and speed recovery in people 65 and older hospitalized with pneumonia.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11282391

• Using systems biology to understand severe community-acquired pneumonia

  This project analyzes patients' lung and blood samples with advanced lab tests and computer models to find biological patterns that can help guide treatment for people with severe pneumonia, including COVID-related cases.

  NIH research Northwestern University · Chicago, United States · NIH-11248062

• Targeted antibiotic treatment for community-acquired pneumonia

  This project uses faster diagnostic tests to help doctors pick and shorten antibiotics for adults hospitalized with community-acquired pneumonia.

  NIH research Cleveland Clinic Foundation · Cleveland, United States · NIH-11161399

• Better ways to find pneumonia in children

  This project aims to create smarter tools to help doctors quickly and accurately diagnose pneumonia in children who come to the emergency room.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11128573

• Investigating the role of ANGPTL4 in severe pneumonia outcomes

  This study is looking at how a protein called ANGPTL4 might influence how well patients with severe pneumonia recover, and it aims to find better ways to help them heal.

  NIH research University of Washington · Seattle, United States · NIH-11047089

• Creating a score to assess the severity of pneumonia in children

  This study is working on a new scoring system to help doctors understand how serious pneumonia is in kids, so they can make better choices about treatment and whether a child needs to stay in the hospital.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11035056

• Modeling severe pneumonia caused by the coronavirus

  This study is looking at how severe pneumonia caused by the coronavirus affects patients, using samples from their lungs to find ways to better predict their recovery and improve treatments.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-11014081

• Improving diagnosis of pneumonia in children using advanced technology

  This study is working on a smart tool to help doctors quickly and accurately diagnose pneumonia in kids using computer data, which could lead to better treatment and less unnecessary medicine.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-10985774

• Improving treatment for pneumonia by using targeted therapies

  This study is looking at how to better identify the germs that cause community-acquired pneumonia so that patients can get the right antibiotics quickly, helping them recover faster and reducing the chances of antibiotic resistance.

  NIH research Cleveland Clinic Foundation · Cleveland, United States · NIH-10906059

• Understanding long-term effects of Gram-negative pneumonia

  This study is looking at how people who have survived a serious lung infection called pneumonia, caused by a specific germ, do over time after leaving the hospital, and it aims to find out what factors might lead to health problems later on so that doctors can provide better care for those who need it.

  NIH research University of Washington · Seattle, United States · NIH-10899457

Related topics

Quick answers

How many Community-acquired Pneumonia clinical trials are recruiting right now?

20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 41 countries. The most sites are in United States (6 trials), France (5 trials), Canada (4 trials), Germany (4 trials), Australia (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 7, Phase 2/3: 1, Phase 4: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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