IL-22’s role in SARS-CoV-2 infection and tissue protection

Who could benefit from this research

What this research studies

This project looks at how IL-22 influences tissue responses during SARS-CoV-2 infection and in the context of graft-versus-host disease. It will explore how IL-22 changes epithelial cell behavior, cell survival, and tissue repair in affected organs like the GI tract and lungs. The research may involve laboratory studies using human cells and tissue samples to see how IL-22 could prevent tissue damage or promote healing in COVID-19–related conditions. Results could point to future therapies that reduce long-term complications after infection. The work aims to translate findings into strategies that help patients recover more fully from COVID-19 and PASC.

Why it matters

Where this research is happening

• University of Oklahoma Hlth Sciences Ctr
  Oklahoma City, United States Active

Researchers

• Principal investigator: Zenewicz, Lauren a — University of Oklahoma Hlth Sciences Ctr
• Study coordinator: Zenewicz, Lauren a

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.