How the right side of the heart uses energy in pulmonary arterial hypertension
The state of energy in the right ventricle of patients with pulmonary arterial hypertension
This project looks at how the right ventricle's blood flow and energy change over time in people with pulmonary arterial hypertension using a 3D echocardiogram technique.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11249689 on NIH RePORTER |
What this research studies
If you have pulmonary arterial hypertension, researchers would use a special 3D echocardiography method called Echo-PIV together with 3D speckle tracking to measure blood flow patterns, kinetic energy, work, and energy loss in your right ventricle. They will compare those noninvasive energy measurements to pressures from right heart catheterization and to your symptoms and clinical status. Imaging and measurements will be repeated during follow-up to see how the RV energy state changes as the condition gets better or worse. The team aims to link changes in the RV energy state with invasive pressure readings and patient outcomes to improve monitoring.
Who could benefit from this research
Good fit: People diagnosed with pulmonary arterial hypertension who are having follow-up care or who experience unexplained clinical worsening are the best candidates.
Not a fit: People without pulmonary arterial hypertension, those with other causes of pulmonary hypertension that affect the left heart, or patients who cannot get usable echocardiographic images may not benefit from this approach.
Why it matters
Potential benefit: If successful, this could offer a noninvasive way to track right heart function and reduce reliance on repeated invasive right heart catheterizations.
How similar studies have performed: This uses a recently developed Echo-PIV technique that has shown promise in measuring right-ventricle flow and energy in early work, but it is not yet established as a clinical replacement for catheter measurements.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Kheradvar, Arash — University of California-Irvine
- Study coordinator: Kheradvar, Arash
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.