Integrative multiomics to find genes and networks in PAH
Official title: Integrative Multiomics to Uncover Novel Genes and Networks in Pulmonary Arterial Hypertension
Funded at University of California Los Angeles · NIH-11393638 · Data updated 2026-11-12
This NIH grant supports a clinician-scientist at UCLA to map genes and networks involved in pulmonary arterial hypertension using cutting-edge multiomics.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | August 10, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $176,580 |
| NIH project number | 5K08HL169982-04 |
| Project ID | NIH-11393638 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with pulmonary arterial hypertension who have had lung tissue and hemodynamic data available for integrative analysis.
✕Less likely to help
Patients without access to comprehensive omics data or who do not have PAH may not directly benefit.
What this research studies
A physician-scientist at UCLA will use advanced omics data from PAH patients to discover new molecular drivers of the disease. The project combines single-cell and spatial biology with computational analyses to identify potential therapeutic targets. By linking lung gene networks to heart catheterization data, the work aims to move toward targeted treatments for PAH patients. The program also emphasizes mentorship and training to help the researcher become an independent PAH scientist.
Why it matters
Potential benefit: If successful, the work could reveal new targets for therapies that slow or reverse PAH progression.
How similar studies have gone: Previous PAH studies using multiomics have identified disease-associated gene modules, with ongoing work translating findings to therapies.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Hong, Jason — University of California Los Angeles
- Study coordinator: Hong, Jason
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.