Condition

Pulmonary Arterial Hypertension (PAH) clinical trials and research

• 23Clinical trials
• 18Countries

Newest Pulmonary Arterial Hypertension (PAH) clinical trials

All recruiting trials (23)

• Sleep problems in PAH patients: how sleep breathing relates to PAH outcomes

  This study tests how sleep-disordered breathing and nocturnal oxygen changes relate to outcomes in adults with pulmonary arterial hypertension.

  Recruiting Chinese Pulmonary Vascular Disease Research Group · Beijing · NCT07852403

• Impact of ambient air vs nasal liquid oxygen on exercise performance in pulmonary vascular disease

  This study tests whether using nasal liquid oxygen during a 6-minute walk test changes how far patients with PAH or CTEPH can walk compared to breathing room air.

  Recruiting University of Zurich · Zurich, Canton of Zurich · NCT07777445

• Liquid oxygen vs ambient air during a 6-minute walk in people with pulmonary vascular disease

  This study tests whether walking with liquid oxygen at about 4 L/min helps or hinders distance walked compared with walking on room air in adults with PAH or CTEPH living in Switzerland.

  Recruiting University of Zurich · Zurich, Canton of Zurich · NCT07777367

• Treprostinil inhalation powder for PAH patients switching from selexipag

  This study tests whether inhaled treprostinil (LIQ861) is safe and tolerable for adults with PAH who are moving from oral selexipag to inhaled therapy.

  Recruiting Phase 4 Liquidia Technologies, Inc. · Columbus, Georgia · NCT07759804

• Escalation options for PAH patients already on dual therapy

  This trial tests whether adding a prostacyclin pathway drug or increasing sildenafil dose helps PAH patients at intermediate-to-high risk who aren’t at low risk despite dual therapy.

  Recruiting Phase 4 University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT07713914

• Vasoactive Agents in Pulmonary Hypertension Crisis

  This trial tests whether dopamine, norepinephrine, or epinephrine can safely and effectively help people with a pulmonary hypertension crisis who are in the hospital.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality and 2 other locations · NCT07667829

• Tele-Pulmonary Rehabilitation for Chronic Lung Diseases

  This study tests whether a remote tele-rehabilitation program helps people with chronic lung diseases start and stick with pulmonary rehab better than usual center-based care.

  Recruiting at 2 sites Tel-Aviv Sourasky Medical Center · Ashkelon and 1 other locations · NCT07666841

• IMC-003 in PAH patients on background therapy

  This study tests whether IMC-003 added to patients’ current PAH treatment can help people with pulmonary arterial hypertension who still have symptoms.

  Recruiting at 13 sites Phase 1/2 ImmuneOnco Biopharmaceuticals (Shanghai) Inc. · Beijing, Beijing Municipality and 28 other locations · NCT07593027

• Improving adherence to inhaled iloprost for pulmonary arterial hypertension

  This project will test whether pharmacist-led inhaler training and adherence support helps adults with pulmonary arterial hypertension who use inhaled iloprost stick to their treatment and reduce side effects.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT07457762

• REGN13335 for adults with pulmonary arterial hypertension (PAH)

  Researchers will test whether the experimental antibody REGN13335 is safe and helps adults with pulmonary arterial hypertension who are already taking other PAH medicines.

  Recruiting at 33 sites Phase 2 Regeneron Pharmaceuticals · Aurora, Colorado and 32 other locations · NCT07318597

• Initial dual oral therapy versus monotherapy for PAH with cardiovascular comorbidities

  This trial will test whether starting both tadalafil and ambrisentan together works better than tadalafil alone for people newly diagnosed with pulmonary arterial hypertension who have at least two heart or vascular health problems.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Le Kremlin-Bicêtre · NCT07245680

• ROC-101 for pulmonary arterial hypertension and pulmonary hypertension from interstitial lung disease (ROCSTAR)

  This trial tests whether adding oral ROC-101 to standard care helps adults with PAH or pulmonary hypertension caused by interstitial lung disease over a 24-week treatment period.

  Recruiting at 24 sites Phase 2 AllRock Bio, Inc. · Phoenix, Arizona and 23 other locations · NCT07175038

• Testing a patient questionnaire about pulmonary hypertension knowledge

  This project will test a questionnaire to measure what adults with pulmonary arterial hypertension know about their condition, treatments, and self-care.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT07120789

• Switching endothelin receptor medicines and risk in pulmonary arterial hypertension

  This study will try switching adults with PAH from ambrisentan to bosentan to see if the change alters their clinical risk profile and liver safety.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT07013149

• Timing of pulmonary arterial hypertension diagnosis in Brazil

  We will see how long it takes adults with pulmonary arterial hypertension in Brazil to get a confirmed diagnosis and what causes delays.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT06998329

• Sequential versus initial combination treatment for pulmonary arterial hypertension

  This trial tests whether starting with one drug and adding the second later works as well as starting both ambrisentan and tadalafil together for adults with PAH.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06968962

• Exercise program for patients with pulmonary arterial hypertension receiving sotatercept

  This study is testing whether a special exercise program combined with a new medication can help people with pulmonary arterial hypertension feel better and improve their ability to exercise.

  Recruiting Phase 3 University of Washington · Seattle, Washington · NCT06941441

• Evaluating inhalable Imatinib for treating pulmonary hypertension and lung fibrosis

  This study is testing a new inhalable medication called XHALIP to see if it can help people with pulmonary hypertension and lung fibrosis feel better by improving their lung health.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia, Pavia · NCT06917196

• Daily oral artesunate for people with pulmonary arterial hypertension — safety and tolerability

  Over 20 weeks, adults with pulmonary arterial hypertension will try daily oral artesunate to see if it is safe and tolerable.

  Recruiting Phase 1 Stanford University · Stanford, California · NCT06872112

• Home monitoring for cardiac issues in systemic sclerosis patients

  This study is testing if home monitoring can help people with systemic sclerosis-related lung high blood pressure keep track of their symptoms and health better than regular hospital visits.

  Recruiting Oslo University Hospital · Oslo · NCT06865118

• Improving adherence to PAH treatment with telemedicine and patient guidance

  This study will try whether regular telemedicine check-ins and guided education help people with PAH stick to their oral medications and manage side effects.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT06850792

• Sotatercept to support right ventricular function in pulmonary arterial hypertension

  This research will try sotatercept injections in adults with PAH to see if the medicine helps the right side of the heart work better.

  Recruiting Phase 4 Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT06658522

• Registry for patients with pulmonary hypertension and their treatment outcomes

  This study is collecting information from patients with pulmonary hypertension who have just started treatment to see how well different therapies are working in real-life settings.

  Recruiting at 7 sites Technische Universität Dresden · Leuven and 6 other locations · NCT01347216

Related topics

Quick answers

How many Pulmonary Arterial Hypertension (PAH) clinical trials are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in Brazil (6 trials), United States (5 trials), China (4 trials), Germany (3 trials), Italy (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 3: 2, Phase 2: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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