Endothelial and smooth muscle cell programs in pulmonary arterial hypertension
Official title: Project 3: Endothelial and smooth muscle cell programs for pulmonary arterial hypertension
Funded at Stanford University · NIH-11391267 · Data updated 2026-11-12
A study in mice will map how genes in lung blood vessel cells influence pulmonary arterial hypertension and identify factors that might protect against or worsen the disease.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 15, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $445,061 |
| NIH project number | 5P01HL180323-02 |
| Project ID | NIH-11391267 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patient participants in this grant, as it is a preclinical, animal-model study.
✕Less likely to help
No direct patient participation is involved in this preclinical research.
What this research studies
This project looks at how endothelial and smooth muscle cells in the lungs contribute to PAH by testing thousands of gene tweaks in a mouse model. Researchers will use a targeted CRISPR-based approach to perturb genes in lung endothelial cells and observe the resulting changes in cell behavior and gene expression. The goal is to uncover gene networks that drive disease or offer protection, considering how genetics and environment shape these effects. Findings could point to new avenues for therapies that target specific cell pathways in PAH patients.
Why it matters
Potential benefit: If successful, the work could reveal new targets for treatments that slow or halt PAH progression.
How similar studies have gone: Similar perturb-seq approaches have identified gene networks driving vascular diseases in other models, suggesting the approach could yield actionable insights for PAH.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Rabinovitch, Marlene — Stanford University
- Study coordinator: Rabinovitch, Marlene
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.