Condition

Peripheral Neuropathy clinical trials and research

• 18Clinical trials
• 74NIH research projects
• 7Countries

Newest Peripheral Neuropathy clinical trials

All recruiting trials (18)

• Cryoneurolysis for Chronic Pain: 6- and 12-Month Outcomes in Routine Care

  This study tests whether cryoneurolysis, done as part of standard care for people with chronic pain, leads to meaningful improvements over 6 to 12 months.

  Recruiting Yale University · Old Saybrook, Connecticut · NCT07639060

• Acupuncture and Exercise for EV-Pembro–Induced Peripheral Neuropathy

  This study tests whether adding acupuncture to a gentle virtual exercise program helps reduce chemotherapy-induced nerve problems in bladder cancer patients taking EV and pembrolizumab.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT07548476

• Tai Chi, alpha-lipoic acid, and acupuncture to reduce chemotherapy-related peripheral neuropathy in people treated for gastrointestinal cancers.

  This 16-week pilot will try virtual Tai Chi/Qi Gong or alpha-lipoic acid, adding acupuncture for those who don't improve, to see if these approaches reduce chemo-related nerve numbness and tingling in people treated for GI cancers.

  Recruiting Thomas Jefferson University · Philadelphia, Pennsylvania · NCT07501663

• Adaptive transcutaneous magnetic stimulation for posttraumatic peripheral neuropathic pain

  This project will try adaptive transcutaneous magnetic stimulation (AtMS) to see if it reduces post-traumatic peripheral neuropathic pain in veterans and active-duty military.

  Recruiting Veterans Medical Research Foundation · San Diego, California · NCT07301177

• Leia sensory prosthesis for balance and gait in people with peripheral neuropathy

  A wearable, non-invasive device is tested to see if it helps adults with peripheral neuropathy walk more stably and balance better over a set period.

  Recruiting Mynerva Ag · Meyrin and 2 other locations · NCT07236515

• Desloratadine to see if it can prevent nerve damage from taxane chemotherapy in breast cancer

  A randomized, placebo-controlled test to see if desloratadine can help prevent taxane-induced peripheral neuropathy in adults with breast cancer.

  Recruiting Phase 2 Montefiore Medical Center · The Bronx, New York · NCT07109817

• Nerve excitability testing for cisplatin-related peripheral neuropathy

  This study will see if specialized nerve excitability tests (TTNCS) can detect early nerve changes in adults starting cisplatin or who recently finished cisplatin and have peripheral neuropathy.

  Recruiting Beth Israel Deaconess Medical Center · Boston, Massachusetts and 1 other locations · NCT07095998

• Fenofibrate to prevent nerve damage from VRd (bortezomib/lenalidomide/dexamethasone) in multiple myeloma

  This tests whether adding fenofibrate to standard VRd chemotherapy can reduce bortezomib-related peripheral neuropathy in adults newly diagnosed with multiple myeloma.

  Recruiting at 2 sites Phase 4 Tanta University · Damanhur, El- Behira and 1 other locations · NCT07025005

• Real-time pressure controller to prevent peripheral neuropathy from albumin-bound paclitaxel

  This trial will test whether a real-time pressure controller can reduce numbness, tingling, and nerve pain in adults getting albumin-bound paclitaxel for breast cancer.

  Recruiting Tianjin Medical University Cancer Institute and Hospital · Tianjin · NCT07019233

• Using ultrasound to improve diagnosis of nerve disorders like GBS and CIDP

  This study is testing if using ultrasound can help doctors better diagnose nerve disorders like Guillain-Barré Syndrome and CIDP by comparing ultrasound results with other nerve tests.

  Recruiting Assiut University · Asyut · NCT06615622

• Assessing gait and balance in rare neurological diseases

  This study looks at how walking and balance are affected in people with rare neurological diseases to better understand their challenges and risks of falling.

  Recruiting Istituto Auxologico Italiano · Milan, Milan and 1 other locations · NCT06343558

• Assessing force measurement in carbon fiber orthoses

  This study is testing how well special sensors can measure force in carbon fiber ankle-foot braces to see how they work for healthy people and those with nerve issues.

  Recruiting University of Iowa · Iowa City, Iowa · NCT06127264

• Wearable Insoles to Help Prevent Diabetic Foot Ulcers

  This study tests Orpyx sensory insoles added to standard care to see if they reduce diabetic foot ulcers in high-risk adults with neuropathy.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT05950659

• Preventing nerve damage from chemotherapy in colorectal cancer patients

  This study is testing if high doses of omega-3 fatty acids can help prevent nerve damage in colorectal cancer patients who are getting chemotherapy.

  Recruiting at 4 sites Vejle Hospital · Aalborg and 3 other locations · NCT05404230

• Using ultrasound to study nerves and muscles

  This study is testing how ultrasound can help us learn more about the health of nerves and muscles in both healthy adults and those with neuromuscular disorders.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05237973

• Using stem cell exosomes to treat Trigeminal Neuralgia

  This study is testing if a treatment using stem cell exosomes can help people with Trigeminal Neuralgia feel better and reduce their pain.

  Recruiting at 2 sites Phase 1 The Foundation for Orthopaedics and Regenerative Medicine · Naples, Florida and 1 other locations · NCT05152368

• Intermittent Dorsal Root Ganglion Stimulation for Chronic Pain Relief

  This study is testing if a new way of using nerve stimulation can help people with chronic pain feel better compared to the usual constant treatment.

  Recruiting Rush University Medical Center · Chicago, Illinois · NCT04909138

• Investigating the role of amylin in diabetic nerve damage

  This study is trying to see if the levels of a hormone called amylin are linked to nerve damage in people with Type-2 diabetes.

  Recruiting University of Kentucky · Lexington, Kentucky and 1 other locations · NCT03481283

NIH-funded research (newest 40 of 74)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Non-invasive, microscopic biomarkers to detect CIPN in chemotherapy patients

  This grant aims to develop a non-invasive imaging method to measure nerve changes in patients undergoing chemotherapy to better understand and monitor chemotherapy-induced peripheral neuropathy (CIPN).

  NIH research University of Arizona · Tucson, United States · NIH-11473607

• Novel pain biomarker for neuropathy that could guide therapy

  A study to develop and test a biomarker that reflects how well peripherally acting pain medicines work for people with painful peripheral neuropathy.

  NIH research Lasmed, LLC · Mountain View, United States · NIH-11416173

• Auricular vagus nerve stimulation to help HIV-related nerve pain in older adults

  A new, non-invasive brain-nerve stimulation approach is being tested to help older adults living with HIV who have nerve pain.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11411053

• Longitudinal study of how body-sense relates to chemotherapy nerve damage

  This study follows people with breast or gastrointestinal cancer and healthy controls to see if brain processing of body sensations contributes to chemotherapy-induced nerve damage.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11398026

• Understanding how early nerve excitement during chemotherapy leads to painful nerve damage

  A cancer treatment study looks at why the nerve pain some patients get after paclitaxel may develop, by studying how nerves react during the infusion.

  NIH research University of Texas Med Br Galveston · Galveston, United States · NIH-11396222

• A new screen for chemotherapy-related nerve problems in young children

  A clinician-scientist at Yale is developing a child-friendly survey to quickly screen for nerve-related side effects from cancer treatment in kids from birth to age 5.

  NIH research Yale University · New Haven, United States · NIH-11381211

• Understanding nerve damage in Spinocerebellar Ataxia Type 3

  A study in people with SCA3 explores how the disease affects the peripheral nerves and what that means for symptoms like numbness or weakness.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11381061

• How the immune system’s CD4+ T cells in women might prevent chemotherapy-related nerve pain

  A study in mice explores whether female immune cells in nerve tissue can lessen pain from chemotherapy, with potential implications for preventing CIPN in women.

  NIH research University of New England · Biddeford, United States · NIH-11365153

• Axonal transport and chemotherapy-related nerve pain

  This grant studies why certain cancer patients develop painful nerve damage from chemotherapy and explores ways to prevent or treat it.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11350880

• Daily home-based TENS for painful CIPN: phase III confirmatory trial

  A big, multi-site study will test whether a home-based, wireless TENS device can relieve painful chemotherapy-induced peripheral neuropathy in cancer patients.

  NIH research University of Rochester · Rochester, United States · NIH-11339044

• Remote monitoring and nurse follow-up to manage chemotherapy-induced peripheral neuropathy

  A program uses symptom reporting tools with nurse follow-up to reduce and better manage chemotherapy-induced neuropathy for cancer survivors, during and after treatment.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11328854

• Non-opioid pain relief for chemotherapy-related nerve pain using CART II

  A study tests a brain-acting peptide called CART II to help reduce pain from chemotherapy-induced nerve damage without opioids.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11325439

• New oral TAK1 inhibitor to help with chemotherapy-related nerve pain

  A new oral drug candidate aims to prevent or lessen nerve damage and pain caused by certain chemotherapy treatments in cancer patients.

  NIH research Eydis Bio, INC. · Durham, United States · NIH-11312109

• Remotely Delivered Tai Chi to Help Older GI Cancer Patients with Chemotherapy-Related Nerve Pain

  A study will test a home-based Tai Chi program to ease nerve pain and improve function for GI cancer patients aged 65 and older who are experiencing chemotherapy-related neuropathy.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11301594

• Non-invasive microscopic biomarkers to track chemotherapy-caused nerve pain

  A study at the University of Arizona will test a non-invasive imaging method to visualize tiny nerve endings in the skin to help understand and monitor chemotherapy-induced peripheral neuropathy in cancer patients.

  NIH research University of Arizona · Tucson, United States · NIH-11290862

• Gut bacterial vesicles and diabetic nerve damage

  This work looks at whether tiny particles released by gut bacteria can protect nerves and ease numbness and pain in people with diabetic peripheral neuropathy.

  NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11286790

• Predicting nerve damage risk from taxane chemotherapy

  This project builds a tool to predict which patients getting taxane chemotherapy are likely to develop peripheral neuropathy.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11285481

• New ways to prevent and reverse chemotherapy-related nerve damage

  Researchers are trying approaches that block a nerve‑destroying protein to prevent or reverse painful nerve damage in people treated with chemotherapy.

  NIH research Washington University · Saint Louis, United States · NIH-11284066

• Restoring sensation in amputated limbs for veterans with diabetic neuropathy

  This study is looking to help veterans who have lost lower limbs due to diabetic peripheral neuropathy by using special electrodes to create sensations that feel like they're coming from their missing foot, which could improve their daily activities and overall limb health.

  NIH research Louis Stokes Cleveland VA Medical Center · Cleveland, United States · NIH-11262790

• Skin nerve–immune links in chemotherapy-related hand and foot nerve pain

  This project looks at how interactions between skin nerves and the immune system may cause long-lasting hand and foot nerve pain after the chemotherapy drug oxaliplatin.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11240287

• Blocking NLRP3 to treat paclitaxel-related nerve pain

  This project looks at whether blocking the NLRP3 inflammasome can help adults who get nerve pain from paclitaxel chemotherapy.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11237999

• Wearable vibration to improve movement and reduce pain in diabetic nerve damage

  A wearable vibration device is tested for four weeks to help adults with diabetic peripheral neuropathy walk better and experience less pain.

  NIH research University of Florida · Gainesville, United States · NIH-11226229

• SP16 to prevent chemotherapy-related nerve damage

  This project tries to prevent or reduce nerve pain and lasting nerve damage from taxane chemotherapy using a new drug called SP16 that activates the LRP1 receptor.

  NIH research Serpin Pharma, LLC · Manassas, UNITED STATES · NIH-11193543

• How the brain's sensing of the body affects chemo-related nerve symptoms

  Researchers will follow people with breast or gastrointestinal cancer getting taxane or platinum chemotherapy and healthy volunteers to learn whether changes in the brain's body-sensing relate to nerve symptoms after chemotherapy.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11182478

• How early nerve over-activation during paclitaxel treatment may cause chemotherapy-related peripheral neuropathy

  This project looks at whether paclitaxel causes early over-activation of sensory nerves that leads to energy failure in nerve fibers and later painful peripheral neuropathy in people treated with paclitaxel.

  NIH research University of Texas Med Br Galveston · Galveston, United States · NIH-11174252

• Improving walking and reducing foot pressure for people with diabetic nerve damage

  This project tries real-time biofeedback to change how adults with diabetic peripheral neuropathy walk so they have lower harmful foot pressure and better walking speed.

  NIH research Florida Institu /human/machine Cognition · Pensacola, United States · NIH-11168786

• Finding new ways to treat painful nerve damage caused by chemotherapy

  This study is looking at the painful nerve damage that some cancer survivors experience from chemotherapy, and it's trying to find new ways to help reduce that pain so they can feel better.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11160833

• Low-Intensity Vibration to Reduce CIPN Symptoms After Chemotherapy

  A home-based, drug-free therapy using a vibrating platform aims to lessen nerve pain and improve movement for adults who have finished chemotherapy.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11159321

• Investigating how microRNA affects nerve protection to reduce pain from chemotherapy and Alzheimer's.

  This study is looking at how a tiny molecule and a specific protein might help protect nerves from damage caused by chemotherapy and Alzheimer's, using fruit fly larvae to learn more about nerve pain and find new ways to help people feel better.

  NIH research University of Chicago · Chicago, United States · NIH-11135937

• How immune cells in women might protect against nerve pain from chemotherapy

  This project explores how certain immune cells in female bodies may naturally reduce nerve pain caused by chemotherapy, aiming to find new ways to prevent this side effect.

  NIH research University of New England · Biddeford, United States · NIH-11132670

• New treatments for nerve pain caused by chemotherapy

  This study is looking for new medications to help manage nerve pain that some people experience after chemotherapy, focusing on a protein called CRMP2, with the hope of finding safer treatments that don't involve opioids.

  NIH research University of Florida · Gainesville, United States · NIH-11126912

• Managing nerve pain caused by chemotherapy through remote monitoring

  This study is testing a new way to help people who have painful nerve issues after chemotherapy by using a symptom reporting tool and follow-up calls from nurses to make sure they get the support they need.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11124630

• New methods to detect nerve damage from chemotherapy

  This study is looking at a new way to see and measure nerve damage in the skin caused by chemotherapy, which can help doctors better understand and manage the symptoms for cancer patients dealing with nerve pain.

  NIH research University of Arizona · Tucson, United States · NIH-11121422

• Mobile app teaching caregivers massage techniques for chemotherapy-related nerve pain

  This study is creating a friendly mobile app called 'Peripheral Neuropathy Relief' to help caregivers learn easy massage techniques that can ease the discomfort of cancer survivors dealing with nerve pain from chemotherapy.

  NIH research Collinge and Associates · Eugene, United States · NIH-11115814

• Understanding and treating nerve damage from chemotherapy

  This project looks at how chemotherapy causes nerve damage in cancer patients.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11110471

• Antibody-based treatment for nerve pain from oxaliplatin chemotherapy

  This project tests a small engineered antibody-like drug to relieve long-lasting nerve pain in people treated with oxaliplatin chemotherapy.

  NIH research Albuquerque VA Medical Center · Albuquerque, United States · NIH-11109402

• Understanding how aging cells contribute to nerve pain after chemotherapy

  This study is looking at how certain aging cells in the body might cause the painful nerve problems that some cancer survivors experience after chemotherapy, with the hope of finding new ways to help manage or prevent these symptoms.

  NIH research Washington University · Saint Louis, United States · NIH-11108403

• Investigating how microRNA affects nerve protection to reduce pain from chemotherapy

  This study is looking at how tiny molecules called microRNAs can help a protein that protects nerves from damage caused by chemotherapy, with the hope of finding new ways to help people who experience nerve pain after cancer treatment.

  NIH research University of Chicago · Chicago, United States · NIH-11105365

• Spinal cord stimulation for nerve pain from chemotherapy and better cancer treatment

  This project explores how spinal cord stimulation might reduce nerve pain caused by chemotherapy and improve the effectiveness of cancer drugs.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11098559

• Investigating a new treatment for pain caused by chemotherapy

  This study is looking at a new treatment called CART II to help relieve the painful nerve issues that some cancer patients experience after chemotherapy, and it aims to find a safer way to manage that pain for everyone.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11088839

Related topics

Quick answers

How many Peripheral Neuropathy clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (12 trials), Egypt (2 trials), Greece (1 trial), Switzerland (1 trial), Denmark (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 1, Phase 4: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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