NIH-funded research Career grant

Improving walking and reducing foot pressure for people with diabetic nerve damage

Official title: Walking Function in Individuals with Diabetic Peripheral Neuropathy: Biomechanical Mechanisms and Implications for Clinical Outcomes and Gait Retraining

Funded at Florida Institu /human/machine Cognition · NIH-11168786 · Data updated 2026-11-12

This project tries real-time biofeedback to change how adults with diabetic peripheral neuropathy walk so they have lower harmful foot pressure and better walking speed.

More Neuropathy research and trials

Quick facts

Grant typeCareer grant
Study typeNIH-funded research
Funding institutionFlorida Institu /human/machine Cognition
NIH-funded
Lab location1 site (Pensacola, United States)
Project startSeptember 1, 2022
Project endAugust 31, 2027
Funding year2025
Award (this year)$131,085
NIH project number5K01HD107294-05
Project IDNIH-11168786 on NIH RePORTER

Who could benefit from this research

Could help

Adults (21+) with diabetic peripheral neuropathy who have abnormal gait or reduced walking speed and can walk during testing would be the ideal candidates.

Less likely to help

People without diabetic neuropathy, those unable to walk safely, or individuals with active foot ulcers or recent lower-limb amputation may not benefit or be eligible.

What this research studies

You would have your walking measured with motion-capture and pressure-sensing equipment to see how your foot loads and how much push-off (propulsion) you generate. Researchers will compare these gait measures in people with diabetic peripheral neuropathy to identify patterns linked to ulcers and poor walking. During some sessions you would get real-time biofeedback while walking to try shifting pressure and propulsion in safer ways. The team will monitor safety and feasibility to see whether this kind of tailored gait training could avoid increasing ulcer risk.

Why it matters

Potential benefit: If successful, this could lower risky foot pressure, reduce ulcer and amputation risk, and help people with diabetic neuropathy walk better.

How similar studies have gone: Gait biofeedback has shown promise in other groups, but its safety and effectiveness specifically for reducing plantar pressure in diabetic neuropathy is still relatively untested.

Where this research is happening

  • Florida Institu /human/machine Cognition
    Pensacola, United States
    Active

Researchers

  • Principal investigator: Rendos, Nicole Kristen — Florida Institu /human/machine Cognition
  • Study coordinator: Rendos, Nicole Kristen

Related research

Other NIH-funded projects on the same topics.

  • Gut bacterial vesicles and diabetic nerve damage

    This work looks at whether tiny particles released by gut bacteria can protect nerves and ease numbness and pain in people with diabetic peripheral neuropathy.

    NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11286790

  • Restoring sensation in amputated limbs for veterans with diabetic neuropathy

    This study is looking to help veterans who have lost lower limbs due to diabetic peripheral neuropathy by using special electrodes to create sensations that feel like they're coming from their missing foot, which could improve their daily activities and overall limb health.

    NIH research Louis Stokes Cleveland VA Medical Center · Cleveland, United States · NIH-11262790

  • Wearable vibration to improve movement and reduce pain in diabetic nerve damage

    A wearable vibration device is tested for four weeks to help adults with diabetic peripheral neuropathy walk better and experience less pain.

    NIH research University of Florida · Gainesville, United States · NIH-11226229

  • Exploring how gut bacteria affect nerve damage in diabetes

    This study is looking at how tiny particles from gut bacteria might help protect nerves in people with diabetic peripheral neuropathy, which is a common issue for those with diabetes, and it hopes to find new ways to improve nerve health through better gut health.

    NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11046549

  • Investigating how tau phosphorylation affects nerve damage in diabetes

    This study is looking into how problems with insulin and a protein called tau affect nerve health in people with Type 1 Diabetes, with the hope of finding new ways to ease the pain and improve life for those dealing with diabetic nerve issues.

    NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-10980022

  • New treatment for painful diabetic nerve damage using cannabidiol and palmitoylethanolamide tablets

    This study is testing a new type of tablet that combines two ingredients to help relieve pain for people with painful diabetic peripheral neuropathy, aiming to provide relief without the side effects of regular pain medications.

    NIH research Pure Green Pharmaceuticals, INC. · West Bloomfield, United States · NIH-10932267

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.