NIH-funded research R01 grant

Wearable vibration to improve movement and reduce pain in diabetic nerve damage

Official title: Wearable focal vibration on mobility and pain in patients with diabetic peripheral neuropathy

Funded at University of Florida · NIH-11226229 · Data updated 2026-11-12

A wearable vibration device is tested for four weeks to help adults with diabetic peripheral neuropathy walk better and experience less pain.

More Neuropathy research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Florida
NIH-funded
Lab location1 site (Gainesville, United States)
Project startSeptember 3, 2026
Project endAugust 31, 2029
Funding year2026
Award (this year)$1,497,985
NIH project number1R01DK141800-01A1
Project IDNIH-11226229 on NIH RePORTER

Who could benefit from this research

Could help

Adults aged 21 and older with diabetic peripheral neuropathy experiencing abnormal gait and pain.

Less likely to help

Some patients may not experience noticeable improvement in mobility or pain with this intervention.

What this research studies

This project tests a wearable focal vibration device over eight weeks in adults with diabetic peripheral neuropathy. Participants will wear the device for four weeks, with a sham version used for comparison to see its effect on mobility and pain, and follow-up assessments at four weeks post-treatment. The study aims to identify who benefits most and what factors influence response, with results to help guide future care for neuropathy-related mobility and pain. If successful, this approach could become a convenient, non-drug option to improve daily function and comfort for people living with DPN.

Why it matters

Potential benefit: If successful, patients could experience better mobility and less pain from a wearable, non-invasive therapy.

How similar studies have gone: Preliminary data suggest wearable focal vibration may improve mobility and reduce pain, supporting further testing in a larger trial.

Where this research is happening

  • University of Florida
    Gainesville, United States
    Active

Researchers

  • Principal investigator: Wang, Hongwu — University of Florida
  • Study coordinator: Wang, Hongwu

Related research

Other NIH-funded projects on the same topics.

  • Gut bacterial vesicles and diabetic nerve damage

    This work looks at whether tiny particles released by gut bacteria can protect nerves and ease numbness and pain in people with diabetic peripheral neuropathy.

    NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11286790

  • Restoring sensation in amputated limbs for veterans with diabetic neuropathy

    This study is looking to help veterans who have lost lower limbs due to diabetic peripheral neuropathy by using special electrodes to create sensations that feel like they're coming from their missing foot, which could improve their daily activities and overall limb health.

    NIH research Louis Stokes Cleveland VA Medical Center · Cleveland, United States · NIH-11262790

  • Improving walking and reducing foot pressure for people with diabetic nerve damage

    This project tries real-time biofeedback to change how adults with diabetic peripheral neuropathy walk so they have lower harmful foot pressure and better walking speed.

    NIH research Florida Institu /human/machine Cognition · Pensacola, United States · NIH-11168786

  • Exploring how gut bacteria affect nerve damage in diabetes

    This study is looking at how tiny particles from gut bacteria might help protect nerves in people with diabetic peripheral neuropathy, which is a common issue for those with diabetes, and it hopes to find new ways to improve nerve health through better gut health.

    NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11046549

  • Investigating how tau phosphorylation affects nerve damage in diabetes

    This study is looking into how problems with insulin and a protein called tau affect nerve health in people with Type 1 Diabetes, with the hope of finding new ways to ease the pain and improve life for those dealing with diabetic nerve issues.

    NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-10980022

  • New treatment for painful diabetic nerve damage using cannabidiol and palmitoylethanolamide tablets

    This study is testing a new type of tablet that combines two ingredients to help relieve pain for people with painful diabetic peripheral neuropathy, aiming to provide relief without the side effects of regular pain medications.

    NIH research Pure Green Pharmaceuticals, INC. · West Bloomfield, United States · NIH-10932267

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.