Low-Intensity Vibration to Reduce CIPN Symptoms After Chemotherapy
Official title: LIVe: Efficacy of Low Intensity Vibration Therapy to Reduce Symptoms of Peripheral Neuropathy and Preserve Functional Mobility After Chemotherapy for Cancer
Funded at Oregon Health & Science University · NIH-11159321 · Data updated 2026-11-12
A home-based, drug-free therapy using a vibrating platform aims to lessen nerve pain and improve movement for adults who have finished chemotherapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | August 15, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $544,420 |
| NIH project number | 1R01CA298345-01A1 |
| Project ID | NIH-11159321 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+) who have completed neurotoxic chemotherapy and are experiencing CIPN symptoms.
✕Less likely to help
Some participants may not experience noticeable improvement in CIPN symptoms or mobility.
What this research studies
This project tests whether standing on a small vibrating platform at home can ease chemotherapy-related nerve pain and improve balance and walking. Participants would follow a simple routine over several weeks, with regular check-ins to monitor safety and progress. The study focuses on people who have completed certain cancer treatments and are dealing with CIPN symptoms that affect daily life.
Why it matters
Potential benefit: If successful, patients could experience less numbness and pain and better mobility after chemotherapy.
How similar studies have gone: Previous work suggests vibration therapy is safe and may help with balance, but rigorous testing in cancer survivors with CIPN is needed.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Winters-Stone, Kerri M — Oregon Health & Science University
- Study coordinator: Winters-Stone, Kerri M
Related research
Other NIH-funded projects on the same topics.
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Non-invasive, microscopic biomarkers to detect CIPN in chemotherapy patients
This grant aims to develop a non-invasive imaging method to measure nerve changes in patients undergoing chemotherapy to better understand and monitor chemotherapy-induced peripheral neuropathy (CIPN).
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Longitudinal study of how body-sense relates to chemotherapy nerve damage
This study follows people with breast or gastrointestinal cancer and healthy controls to see if brain processing of body sensations contributes to chemotherapy-induced nerve damage.
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A new screen for chemotherapy-related nerve problems in young children
A clinician-scientist at Yale is developing a child-friendly survey to quickly screen for nerve-related side effects from cancer treatment in kids from birth to age 5.
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How the immune system’s CD4+ T cells in women might prevent chemotherapy-related nerve pain
A study in mice explores whether female immune cells in nerve tissue can lessen pain from chemotherapy, with potential implications for preventing CIPN in women.
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Axonal transport and chemotherapy-related nerve pain
This grant studies why certain cancer patients develop painful nerve damage from chemotherapy and explores ways to prevent or treat it.
-
Remote monitoring and nurse follow-up to manage chemotherapy-induced peripheral neuropathy
A program uses symptom reporting tools with nurse follow-up to reduce and better manage chemotherapy-induced neuropathy for cancer survivors, during and after treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.