Investigating how microRNA affects nerve protection to reduce pain from chemotherapy
microRNA regulation of NMNAT-mediated Neuroprotection against Peripheral Neuropathy and Chronic Pain
This study is looking at how tiny molecules called microRNAs can help a protein that protects nerves from damage caused by chemotherapy, with the hope of finding new ways to help people who experience nerve pain after cancer treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11105365 on NIH RePORTER |
What this research studies
This research focuses on understanding how microRNA regulates a protein called NMNAT, which may help protect nerves from damage caused by chemotherapy. By using a model organism, Drosophila larvae, the researchers aim to uncover the biological mechanisms behind chemotherapy-induced peripheral neuropathy (CIPN) and chronic pain. The study seeks to identify new therapeutic targets that could lead to effective treatments for patients suffering from neuropathic pain after cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients experiencing neuropathic symptoms due to chemotherapy.
Not a fit: Patients who do not have chemotherapy-induced peripheral neuropathy or chronic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that alleviate neuropathic pain in cancer patients, improving their quality of life.
How similar studies have performed: Previous research has shown promising results in understanding neuroprotective mechanisms, but this specific approach using microRNA regulation is relatively novel.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Zhai, Rong Grace — University of Chicago
- Study coordinator: Zhai, Rong Grace
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.