Butyrate and Taurine for Chronic Postoperative Pain in Adults after Cardiac Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, phase II, randomized, double-blinded, placebo-controlled trial using a Bayesian design. Adults undergoing elective cardiac procedures via sternotomy are assigned to taurine plus butyrate or placebo to see if the combination lowers chronic postsurgical pain and improves recovery, while assessing safety and perioperative pain control. The trial will enroll up to 216 participants and follow them through the postoperative period to evaluate pain outcomes and adverse events. The investigation is sponsored by The Chinese University of Hong Kong with Prince of Wales Hospital as the site.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients aged 18 or older
* elective surgery
* coronary artery bypass graft (CABG), valve repair/replacement, combined CABG/valve procedure, or major aortic procedure via sternotomy

Exclusion Criteria:

* emergency surgery
* redo surgery
* history of chronic pain or on chronic opioids/sedatives
* already taking taurine or butyrate prior to enrolment
* renal failure with estimated glomerular filtration rate \<30mL/min (calculated by Cockcroft-Gault formula)
* re-operation within 24 hours after surgery
* intraoperative use of remifentanil
* inability to provide informed consent.

Where it's running

• Prince of Wales Hospital
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Henry Wong, MBChB — Department of Anaesthesia and Intensive Care, The Chinese University of Hong Hong
• Study coordinator: Henry Wong, MBChB
• Email: henrymkwong@cuhk.edu.hk
• Phone: 35052734

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.