How obesity in pregnancy affects the metabolism of offspring
Mitochondria mediated changes in obese pregnancies
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-11057293
This study is looking at how being overweight during pregnancy might affect the health of babies by changing how their cells work, and it aims to find out if certain treatments can help prevent weight problems in their future.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11057293 on ClinicalTrials.gov |
What this research studies
This research investigates how maternal obesity impacts mitochondrial function in the offspring, which may lead to obesity and metabolic syndrome later in life. The study focuses on the role of extracellular vesicles produced by adipose tissue during pregnancy, which may carry damaged mitochondrial components to the developing embryo. By using a murine model, researchers will explore how these vesicles influence metabolic health in male embryos and their offspring. The goal is to understand the molecular mechanisms behind these changes and how antioxidant treatment during pregnancy might prevent obesity in the next generation.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals who are classified as obese and are interested in understanding the implications of their condition on their offspring's health.
Not a fit: Patients who are not pregnant or who have a normal weight may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing obesity and metabolic disorders in children born to obese mothers.
How similar studies have performed: Previous research has shown that maternal obesity can negatively affect offspring health, but the specific mechanisms involving mitochondrial function and extracellular vesicles are still being explored.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SIMMONS, REBECCA A — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: SIMMONS, REBECCA A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.