Lipid anti-Inflammatory Mediators in Asthma for Obese Individuals
Official title: LIMA: Lipid anti-Inflammatory Mediators in Asthma to reduce airway hyperresponsiveness in obese asthmatics
Funded at University of Colorado Denver · NIH-11394482 · Data updated 2026-11-12
A study testing a novel lipid-based drug, CXA-10, to help adults with obesity-related asthma breathe better and control their symptoms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | May 1, 2022 |
| Project end | April 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $757,092 |
| NIH project number | 5R33HL157069-05 |
| Project ID | NIH-11394482 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with obesity-associated, late-onset asthma who have not achieved adequate control with conventional therapies.
✕Less likely to help
Individuals without obesity-related asthma or those who do not exhibit airway hyperresponsiveness may not benefit from this drug.
What this research studies
This project will test a new drug called CXA-10, a synthetic molecule inspired by natural anti-inflammatory lipids, in people whose obesity worsens asthma. Researchers will look at lung function (pre-bronchodilator FEV1), asthma symptoms, and airway responsiveness to see if the drug can reduce inflammation and improve control. The study builds on earlier animal work showing anti-inflammatory effects and aims to translate those findings to humans with late-onset, obesity-associated asthma. It involves a Phase 2 evaluation to understand pharmacology and therapeutic impact in this specific patient group.
Why it matters
Potential benefit: If successful, CXA-10 could reduce airway inflammation and improve asthma control in obese adults who respond poorly to standard therapies.
How similar studies have gone: Preclinical studies in obesity-related airway disease showed anti-inflammatory effects and improved airway function, supporting progression to human trials.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Holguin, Fernando — University of Colorado Denver
- Study coordinator: Holguin, Fernando
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.