Condition

Overweight or Obesity clinical trials and research

• 27Clinical trials
• 5NIH research projects
• 17Countries

Newest Overweight or Obesity clinical trials

All recruiting trials (27)

• GZC8072 tablets: safety and how the body handles it after a single dose in healthy people and after multiple doses in people who are overweight or obese

  This study tests GZC8072 tablets to see if they are safe and how they behave in the body after a single dose in healthy adults and after repeated doses in adults who are overweight or obese.

  Recruiting Phase 1 Gan & Lee Pharmaceuticals. · Beijing · NCT07784699

• Just-in-Time Practices to Prevent Weight Regain from Stopping Your Progress

  This trial tests whether sending brief mindfulness and self-compassion exercises right after weight regain or a missed weigh-in helps people stick with their long-term weight goals.

  Recruiting ORI Community and Evaluation Services · Springfield, Oregon · NCT07708064

• Olatorepatide in adults who are overweight or have obesity (without diabetes) test of safety and dosing

  This study tests olatorepatide versus placebo to see if it can safely help adults who are overweight or obese lose weight at different doses.

  Recruiting at 21 sites Phase 2 Regeneron Pharmaceuticals · Mobile, Alabama and 20 other locations · NCT07685808

• Metformin added to antidepressants for depression with obesity in Pakistani adults

  This study tests whether adding metformin to antidepressant therapy helps reduce depressive symptoms and BMI in adults with depression and overweight/obesity in Pakistan.

  Recruiting at 2 sites Riphah International University · Rawalpindi, Punjab Province and 1 other locations · NCT07654179

• Safety and drug levels of REGN20934 in adults with overweight or obesity

  This study tests REGN20934 to see if it is safe and how it behaves in the body in adults who are overweight or have obesity.

  Recruiting Phase 1 Regeneron Pharmaceuticals · Glendale, California · NCT07594093

• SYH2082 Injection: early-dose safety in adults with overweight or obesity

  This early-phase study tests whether a single dose and multiple doses of SYH2082 are safe and well tolerated in healthy adults who are overweight or have obesity.

  Recruiting Phase 1 CSPC ZhongQi Pharmaceutical Technology Co., Ltd. · Nedlands, Western Australia · NCT07532655

• Metformin for older overweight adults with mild cognitive impairment

  This will test whether taking metformin alongside lifestyle changes can help thinking and memory in older overweight adults with mild cognitive impairment.

  Recruiting Phase 1/2 Fudan University · Shanghai · NCT07395960

• Eloralintide for knee osteoarthritis pain in adults with overweight or obesity

  This trial tests whether eloralintide reduces knee osteoarthritis pain in adults who are overweight or have obesity.

  Recruiting at 132 sites Phase 3 Eli Lilly and Company · Mobile, Alabama and 146 other locations · NCT07353931

• Comparing first- and second-generation HRS9531 tablets in people with overweight or obesity

  This study will test whether the second-generation HRS9531 tablet is absorbed differently and is as safe and tolerable as the first-generation tablet in adults who are overweight or obese.

  Recruiting Phase 1 Fujian Shengdi Pharmaceutical Co., Ltd. · Hefei, Anhui · NCT07150962

• Healthy Living BEYOND Weight: a cohort for people living with overweight or obesity.

  This project will follow adults with overweight or obesity to see if different real-world weight management approaches and treatments work and how they affect health over time.

  Recruiting American Heart Association · Dallas, Texas · NCT07075341

• HS-20094 pen treatment for adults with overweight or obesity

  This test will see if two HS-20094 pen devices deliver the medication the same way in adults who are overweight or obese.

  Recruiting Phase 1 Jiangsu Hansoh Pharmaceutical Co., Ltd. · Qingdao, Shandong · NCT07057674

• Whey protein–enriched milk fat globule membrane added to a high‑fat meal to see short‑term heart and brain effects in postmenopausal women

  This trial will test whether adding a whey protein–enriched milk fat globule membrane powder to a high‑fat meal changes short‑term heart and brain health markers in postmenopausal women with overweight and moderate cardiovascular risk.

  Recruiting Loughborough University · Loughborough, Leicestershire · NCT06953232

• Testing MWN109 tablets in healthy adults

  This trial will test MWN109 tablets versus placebo in healthy adults (including people with overweight or obesity) to see if the drug is safe, how the body handles it, and whether it triggers immune responses.

  Recruiting Phase 1 Shanghai Minwei Biotechnology Co., Ltd · Adelaide, South Australia and 1 other locations · NCT06938269

• Investigating the effectiveness of tirzepatide added to ixekizumab for psoriasis and obesity

  This study is testing if adding a weight-loss medication called tirzepatide to an existing psoriasis treatment can help people with moderate-to-severe plaque psoriasis who are also overweight or obese.

  Recruiting at 38 sites Phase 4 Eli Lilly and Company · Phoenix, Arizona and 37 other locations · NCT06857942

• Evaluating SYH9017 for overweight and obesity in Chinese adults

  This study is testing a new medication called SYH9017 to see if it can help Chinese adults who are overweight or obese lose weight safely.

  Recruiting Phase 1 CSPC Baike (Shandong) Biopharmaceutical Co., Ltd. · Beijing, Beijing Municipality · NCT06830343

• Effects of Tirzepatide on Heart Health in Overweight Individuals

  This study tests if tirzepatide can improve heart health and reduce plaque in the arteries of overweight people with stable coronary artery disease.

  Recruiting at 2 sites Phase 4 Steno Diabetes Center Copenhagen · Copenhagen and 2 other locations · NCT06606821

• Park-based programs for youth mental health and resilience

  This study is testing whether a park-based afterschool program can help improve the mental health and resilience of underserved youth aged 12 to 17 in Miami-Dade County.

  Recruiting Duke University · Miami, Florida · NCT06596265

• Examining how emotions affect physical activity engagement

  This study is trying out new ways to see if changing how people feel about exercise can help overweight or obese adults get more active.

  Recruiting University of Southern California · Los Angeles, California · NCT06570642

• Evaluating KN069 for treating obesity in men

  This study is testing a new drug called KN069 to see if it can safely help overweight or obese men feel better and manage their weight.

  Recruiting Phase 1 Suzhou Alphamab Co., Ltd. · Changsha, Hunan · NCT06547775

• Semaglutide to lose weight and reduce body fat to help atrial fibrillation

  This trial will see if adding semaglutide (a prescription weight-loss medicine) to usual care helps adults with obesity and atrial fibrillation have less severe AF or fewer recurrences after treatment.

  Recruiting Phase 3 University of Chicago · Phoenix, Arizona and 1 other locations · NCT06499857

• Neurofeedback for managing food cravings in overweight individuals

  This study tests if neurofeedback can help overweight people with strong food cravings change how their brains respond to food and improve their eating habits.

  Recruiting Yale University · New Haven, Connecticut · NCT06426693

• Evaluating the best time for resistance exercise to improve insulin sensitivity and sleep

  This study is testing whether doing resistance exercises in the morning or evening helps people aged 50-74 with overweight or obesity improve their insulin sensitivity and sleep quality.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06366399

• Behavioral weight reduction program for overweight or obese patients with chronic low back pain

  This study tests if a weight loss program that includes education about pain and special exercises can help overweight or obese people with chronic low back pain feel better compared to just the education and exercises alone.

  Recruiting at 2 sites Vrije Universiteit Brussel · Brussels and 1 other locations · NCT05811624

• Optimizing diet and physical activity for taxi drivers

  This study is trying to help taxi drivers who are overweight or obese make healthier choices about their diet and exercise through personalized support and tools.

  Recruiting Phase 2 Memorial Sloan Kettering Cancer Center · New York, New York · NCT05770570

• Program to reduce obesity and diabetes risks in women planning pregnancy

  This study tests a special online program to help young women who are overweight or obese lower their diabetes and obesity risks before getting pregnant.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT05674799

• Culturally tailored lifestyle counseling for pregnant African American women

  This study is testing a special lifestyle counseling program for pregnant African American women to see if it helps them manage their blood sugar and improve their health during pregnancy.

  Recruiting at 2 sites University of Illinois Chicago · Chicago, Illinois and 1 other locations · NCT05234125

• Weight reduction program for chronic low-back pain

  This study is testing if a weight loss program combined with pain education and exercise can help overweight people with chronic low back pain feel better.

  Recruiting at 2 sites Vrije Universiteit Brussel · Brussels and 1 other locations · NCT04824248

NIH-funded research (5)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Mindful Movement: guided imagery app to boost activity in adults with overweight or obesity

  A researcher-led plan to create and test an easy-to-use guided imagery app that helps adults with overweight or obesity stay more physically active.

  NIH research University of Tennessee Knoxville · Knoxville, United States · NIH-11430590

• Adding yoga to a weight-loss program for adults with overweight or obesity

  This trial compares whether adding regular yoga to a standard behavioral weight-loss program helps adults with overweight or obesity lose more weight over 12 months.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11332631

• Tirzepatide for adults with alcohol use disorder and overweight or obesity

  This will see if the weight-loss medication tirzepatide can help adults with alcohol use disorder who are overweight or obese cut back on drinking and improve health measures.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11192379

• Investigating how yoga can enhance weight loss in adults with obesity

  This study is looking at whether adding yoga to a weight loss program helps adults who are overweight or obese lose more weight and improve their health compared to just doing regular exercise, and you could help us learn more about this by joining!

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11074671

• Evaluating Tirzepatide for treating alcohol use disorder and obesity in adults

  This study is looking at how well Tirzepatide, a new weight loss medication, can help adults who are overweight or obese and also have trouble with alcohol use, by seeing if it can reduce their drinking and help them lose weight for better health.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-10999946

Related topics

Quick answers

How many Overweight or Obesity clinical trials are recruiting right now?

27, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (14 trials), China (7 trials), Belgium (3 trials), Denmark (2 trials), Australia (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 8, Phase 4: 2, Phase 2: 2, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →