How maternal obesity affects asthma risk in children
Mechanisms of airway hyperresponsiveness in the offspring of obese mothers
This study looks at how being overweight during pregnancy might affect a child's chances of developing asthma, using mice to understand how changes in the lungs and nerves happen, with the hope of finding ways to help kids who might be at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11078357 on NIH RePORTER |
What this research studies
This research investigates the link between maternal obesity and the development of asthma in offspring. Using a mouse model that mimics human metabolic conditions, the study explores how maternal obesity leads to changes in airway nerves and increased sensitivity in the lungs. By examining the role of insulin and neurotransmitters, researchers aim to uncover the mechanisms that contribute to airway hyperresponsiveness in children born to obese mothers. The findings could provide insights into potential interventions for at-risk populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are children whose mothers are classified as obese during pregnancy.
Not a fit: Patients who do not have a family history of asthma or obesity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing asthma in children born to obese mothers.
How similar studies have performed: Previous research has indicated a correlation between maternal obesity and increased asthma risk in offspring, suggesting that this approach has a foundation in existing findings.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Nie, Zhenying — Oregon Health & Science University
- Study coordinator: Nie, Zhenying
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.