Investigating the gut bacteria in lean and obese youth with type 1 diabetes and how metformin affects them
The Gut Microbiome in Lean and Obese Youth with Type 1 Diabetes and Novel Mechanism of Action of Metformin
This study is looking at how the bacteria in the gut might be different in kids with type 1 diabetes who are either obese or lean, and it also wants to see if the diabetes medicine metformin can help improve their gut health and insulin use, all to find ways to help these young people feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11099668 on NIH RePORTER |
What this research studies
This research explores the relationship between gut bacteria and obesity in youth with type 1 diabetes (T1D). It aims to profile and compare the gut microbiome of obese and lean children with T1D to understand how these differences may influence their health outcomes. The study also examines how the diabetes medication metformin may alter the gut microbiome and improve insulin sensitivity in these patients. By analyzing these factors, the research seeks to identify potential interventions that could benefit youth with T1D and obesity.
Who could benefit from this research
Good fit: Ideal candidates for this research are youth aged 0-21 years diagnosed with type 1 diabetes, especially those who are obese.
Not a fit: Patients who do not have type 1 diabetes or are not within the age range of 0-21 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for youth with type 1 diabetes, particularly those who are obese.
How similar studies have performed: Previous research has shown promising results in understanding the gut microbiome's role in diabetes management, particularly in adults, but this specific approach in youth with T1D is relatively novel.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Ismail, Hebatullah — Indiana University Indianapolis
- Study coordinator: Ismail, Hebatullah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.