Investigating how innate lymphocytes affect asthma in obese individuals
Role of Innate Lymphocytes in Obese Asthma
This study is looking at how being overweight might make asthma worse, especially in women, by exploring the role of certain immune cells in the body, using a special mouse model that reflects the health issues seen in people; the goal is to find better ways to treat asthma for those who are obese.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11005388 on NIH RePORTER |
What this research studies
This research explores the relationship between obesity and asthma, particularly focusing on how innate lymphocytes contribute to asthma severity in obese patients. The study uses a specialized mouse model that mimics the obesity and metabolic dysfunction seen in women, which is crucial since traditional models have limitations. By examining the immune responses in these mice, researchers aim to uncover the mechanisms that lead to worse asthma outcomes in obese individuals, especially females. The findings could help identify new treatment strategies for managing asthma in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are obese individuals, particularly women, who experience severe asthma symptoms.
Not a fit: Patients with mild asthma who are not obese may not benefit from the findings of this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for asthma in obese patients, particularly women, by targeting specific immune responses.
How similar studies have performed: Previous research has shown promising results in understanding the immune mechanisms in asthma, but this specific approach using a novel mouse model is relatively untested.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Lewkowich, Ian Paul — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Lewkowich, Ian Paul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.