How parental obesity affects kidney disease in their children
Official title: Mechanisms of renal disease progression in offspring from obese parents
Funded at University of Mississippi Med Ctr · NIH-11227049 · Data updated 2026-11-12
This NIH grant investigates why children of obese parents may be more at risk for kidney problems and inflammation, and how certain kidney cells contribute to this risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | September 1, 2026 |
| Project end | April 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $599,993 |
| NIH project number | 1R01DK139245-01A1 |
| Project ID | NIH-11227049 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with a family history of obesity-related kidney disease or those who have experienced acute kidney injury may be relevant for related future studies or trials.
✕Less likely to help
Patients without exposure to obesity-related parental factors or those not at risk for AKI-related progression may see limited benefit.
What this research studies
If funded, researchers at the University of Mississippi Medical Center will study how obesity in parents programs the immune cells in offspring to worsen kidney injury and aging-related kidney disease. They will focus on the purinergic receptor P2X7 and macrophage metabolism to understand inflammatory processes after acute kidney injury. The project plans to test whether reducing macrophage metabolic activity or blocking P2X7R can improve kidney repair and slow disease progression. The work combines animal models and human-relevant analyses to map how early-life exposures shape kidney health over time.
Why it matters
Potential benefit: clearer targets to prevent or lessen kidney inflammation and injury in people born to parents with obesity.
How similar studies have gone: Prior work has shown that manipulating P2X7R and macrophage metabolism can influence kidney inflammation and injury in models.
Where this research is happening
-
University of Mississippi Med Ctr
Jackson, United States Active
Researchers
- Principal investigator: Do Carmo, Jussara M. — University of Mississippi Med Ctr
- Study coordinator: Do Carmo, Jussara M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.