Investigating inflammation and insulin resistance in obese individuals
Adipose Tissue Inflammation and Diabetes Development (Fettvävsinflammation Och Diabetesutveckling)
Göteborg University · NCT04255264
This study is trying to see if certain molecules can help reduce inflammation and insulin resistance in people who are obese and have had gastric bypass surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 18 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Göteborg University (other) |
| Locations | 1 site (Gothenburg, Västra Götaland County) |
| Trial ID | NCT04255264 on ClinicalTrials.gov |
What this trial studies
This observational study examines the role of resolution molecules in reducing inflammation and insulin resistance in human tissue samples from obese individuals. It aims to determine if these effects correlate with specific patient resolution phenotypes. Participants must have undergone gastric bypass surgery at least two years prior and have maintained a stable weight for six months. The study focuses on understanding the biological mechanisms underlying obesity-related complications.
Who should consider this trial
Good fit: Ideal candidates are obese individuals with a BMI between 30-40 kg/m2 who have undergone gastric bypass surgery more than two years ago.
Not a fit: Patients with severe mental illness or significant physical impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new therapeutic strategies for managing obesity-related inflammation and insulin resistance.
How similar studies have performed: While the specific approach of using resolution molecules in this context may be novel, similar studies have shown promise in addressing inflammation in obesity.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * BMI 30-40 kg/m2 * Ptos (i.e. excess skin) \> 3 cm * Patient underwent gastric bypass surgery \>2 years ago * Patient has had a stable weight ≥6 months at the time of operation * Patient does not smoke (min 6 weeks prior to surgery) Exclusion Criteria: * Patients who do not understand spoken and written Swedish * American Society of Anesthesiologists (ASA) classification ≥ 3 * Neurological, orthopedic or rheumatologic injury or illness affecting physical ability * Preoperatively known hernia requiring surgical operation * Severe mental illness
Where this trial is running
Gothenburg, Västra Götaland County
- Sahlgrenska university hospital — Gothenburg, Västra Götaland County, Sweden (RECRUITING)
Study contacts
- Study coordinator: Emma Borgeson, PhD
- Email: emma.borgeson@wlab.gu.se
- Phone: +46313420000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Obese