Predictors of inhaled corticosteroid response in asthma across BMI and race
Official title: Metabolomic and multi-omic predictors of inhaled corticosteroid response in obese and non-obese asthma
Funded at University of Colorado Denver · NIH-11281064 · Data updated 2026-11-12
A patient-focused study aims to find metabolite and genetic signals that predict how well people with asthma, including those who are overweight or from high-risk groups, respond to inhaled steroids.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 7, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $163,414 |
| NIH project number | 1K08HL183790-01 |
| Project ID | NIH-11281064 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with asthma, including those who are overweight or from high-risk racial groups, may contribute samples and data.
✕Less likely to help
Patients with asthma who have typical ICS response or do not contribute samples may see no direct benefit.
What this research studies
This NIH-funded K08 project will look at metabolomic and multi-omic data to understand why some patients with asthma do not respond well to inhaled corticosteroids. Researchers will analyze metabolite profiles and genetic information to identify patterns linked to better or worse ICS response, with a focus on obesity and non-White populations. The study envisions integrating metabolomics with genetics to uncover mechanisms and potential targets that could guide personalized treatment in the future.
Why it matters
Potential benefit: If successful, the findings could lead to more personalized asthma therapy, reducing symptoms and flares for people who currently respond poorly to standard inhaled steroids.
How similar studies have gone: Previous research suggests metabolomic and genetic factors influence drug response, but this project aims to link these factors specifically to ICS response in diverse populations.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Althoff, Meghan Dolan — University of Colorado Denver
- Study coordinator: Althoff, Meghan Dolan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.