EVOLVE-MR: Extending Valve-Surgery Outcomes to Real-World Patients with Mitral Regurgitation
Official title: EVOLVE-MR: Extending Valve-Surgery Outcomes from Landmark Trials to Varied Everyday Patients with Mitral Regurgitation
Funded at Icahn School of Medicine at Mount Sinai · NIH-11466111 · Data updated 2026-11-12
Aims to make the evidence from landmark valve surgery trials applicable to the everyday patients with mitral regurgitation by linking trial data with Medicare records to understand real-world outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 10, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $3,605,083 |
| NIH project number | 1R01HL189182-01 |
| Project ID | NIH-11466111 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 21 and older who undergo valve surgery and are represented in CTSN trials or Medicare data, including older, multimorbid, and diverse patients.
✕Less likely to help
Patients not undergoing valve surgery or those not represented in the linked trial/claims data may not directly benefit.
What this research studies
This project will combine data from major valve surgery trials with Medicare records to see how trial results apply to older and sicker patients seen in everyday practice. Researchers will create a reproducible, de-identified data framework that aligns trial and claims data to study who benefits most from valve surgery. The goal is to estimate how outcomes vary across real-world patient groups and to generalize trial findings beyond specialized centers. The work will produce analysis code and documentation so other researchers can reuse the approach for broader questions in valvular disease care. This could ultimately help clinicians tailor treatments for diverse patients facing valve surgery.
Why it matters
Potential benefit: If successful, patients could receive more personalized recommendations for valve surgery based on real-world outcomes across diverse populations.
How similar studies have gone: Prior CTSN trials established surgical benchmarks; this project tests generalizability in real-world populations, which is a more novel application but builds on established data linkages.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Suarez-Farinas, Mayte — Icahn School of Medicine at Mount Sinai
- Study coordinator: Suarez-Farinas, Mayte
Related research
Other NIH-funded projects on the same topics.
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This study is looking at how two different treatments for degenerative mitral regurgitation—one done through a small tube and the other through traditional surgery—affect patients' health and experiences, so we can better understand which option might work best for you over time.
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This study looks at how the heart changes when someone has mitral regurgitation, a common heart valve problem, and aims to understand why the heart can become enlarged and weak over time, which could help find better ways to treat patients with this condition.
-
Improving treatment predictions for heart patients with mitral valve issues
This study is looking at how to better understand and treat heart problems in people with non-ischemic cardiomyopathy and leaky heart valves, using advanced imaging techniques to help doctors choose the best treatments for each patient.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.