Improving treatment for mitral regurgitation using personalized imaging techniques

Who could benefit from this research

What this research studies

This research focuses on enhancing the treatment of mitral regurgitation, a serious heart condition where the mitral valve does not close properly, allowing blood to flow backward. The team is developing a noninvasive imaging method to assess the shape and movement of the mitral valve in real-time, which could help tailor treatment options like the MitraClip procedure to individual patients. By analyzing patient-specific data, the goal is to predict which patients will benefit most from specific interventions, ultimately improving outcomes. The approach combines advanced 3-D echocardiography and modeling techniques to create a more personalized treatment plan.

Why it matters

Where this research is happening

• University of Texas at Austin
  Austin, United States Active

Researchers

• Principal investigator: Simonian, Natalie — University of Texas at Austin
• Study coordinator: Simonian, Natalie

Related research

Other NIH-funded projects on the same topics.

• EVOLVE-MR: Extending Valve-Surgery Outcomes to Real-World Patients with Mitral Regurgitation

  Aims to make the evidence from landmark valve surgery trials applicable to the everyday patients with mitral regurgitation by linking trial data with Medicare records to understand real-world outcomes.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11466111

• Decoupling heart valve fibrosis from ventricular remodeling in degenerative mitral regurgitation

  A medication-based approach aims to block a specific serotonin receptor to prevent harmful changes in the heart valve and surrounding tissue for people with degenerative mitral regurgitation.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11401987

• Why the heart enlarges with mitral valve leakage (mitral regurgitation)

  This project looks at how leaking of the mitral valve causes heart muscle cells to stretch and the left ventricle to enlarge in adults with mitral regurgitation.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11321256

• Better defining non-ischemic cardiomyopathy with functional mitral regurgitation to predict treatment outcomes

  The team will use advanced heart MRI to better classify people with non-ischemic cardiomyopathy and functional mitral regurgitation so doctors can predict which treatments may work best.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11319841

• Comparing two treatments for severe mitral regurgitation

  This study is looking at how two different treatments for degenerative mitral regurgitation—one done through a small tube and the other through traditional surgery—affect patients' health and experiences, so we can better understand which option might work best for you over time.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11135718

• Understanding heart muscle changes due to mitral valve problems

  This study looks at how the heart changes when someone has mitral regurgitation, a common heart valve problem, and aims to understand why the heart can become enlarged and weak over time, which could help find better ways to treat patients with this condition.

  NIH research University of Utah · Salt Lake City, United States · NIH-11075371

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.