Comparing two treatments for severe mitral regurgitation
Official title: Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation: A Comparative Study of Clinical Outcomes, Patient Experiences, and Mechanistic Insights with Multimodality Imaging
Funded at Cedars-Sinai Medical Center · NIH-11135718 · Data updated 2026-11-12
This study is looking at how two different treatments for degenerative mitral regurgitation—one done through a small tube and the other through traditional surgery—affect patients' health and experiences, so we can better understand which option might work best for you over time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $834,249 |
| NIH project number | 1R56HL175516-01 |
| Project ID | NIH-11135718 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with severe degenerative mitral regurgitation, particularly those over 75 years old.
✕Less likely to help
Patients with mild mitral regurgitation or those who are not candidates for either treatment option may not benefit from this research.
What this research studies
This research investigates the differences in clinical outcomes and patient experiences between two treatment options for degenerative mitral regurgitation: transcatheter edge-to-edge repair and traditional surgical repair. By following approximately 1,800 patients over a decade, the study aims to gather comprehensive data on the effectiveness, safety, and long-term results of each treatment. Patients will undergo multimodality imaging to assess their heart function and recovery, providing valuable insights into which approach may be more beneficial. The goal is to fill existing knowledge gaps and improve treatment decisions for patients with this condition.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and better outcomes for patients with degenerative mitral regurgitation.
How similar studies have gone: While there have been advancements in treatment for mitral regurgitation, this research is novel as it aims to directly compare the two main treatment options in a large cohort over an extended period.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Gupta, Aakriti — Cedars-Sinai Medical Center
- Study coordinator: Gupta, Aakriti
Related research
Other NIH-funded projects on the same topics.
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EVOLVE-MR: Extending Valve-Surgery Outcomes to Real-World Patients with Mitral Regurgitation
Aims to make the evidence from landmark valve surgery trials applicable to the everyday patients with mitral regurgitation by linking trial data with Medicare records to understand real-world outcomes.
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Decoupling heart valve fibrosis from ventricular remodeling in degenerative mitral regurgitation
A medication-based approach aims to block a specific serotonin receptor to prevent harmful changes in the heart valve and surrounding tissue for people with degenerative mitral regurgitation.
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Why the heart enlarges with mitral valve leakage (mitral regurgitation)
This project looks at how leaking of the mitral valve causes heart muscle cells to stretch and the left ventricle to enlarge in adults with mitral regurgitation.
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Better defining non-ischemic cardiomyopathy with functional mitral regurgitation to predict treatment outcomes
The team will use advanced heart MRI to better classify people with non-ischemic cardiomyopathy and functional mitral regurgitation so doctors can predict which treatments may work best.
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Understanding heart muscle changes due to mitral valve problems
This study looks at how the heart changes when someone has mitral regurgitation, a common heart valve problem, and aims to understand why the heart can become enlarged and weak over time, which could help find better ways to treat patients with this condition.
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Improving treatment predictions for heart patients with mitral valve issues
This study is looking at how to better understand and treat heart problems in people with non-ischemic cardiomyopathy and leaky heart valves, using advanced imaging techniques to help doctors choose the best treatments for each patient.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.