Comparing two treatments for severe mitral regurgitation
Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation: A Comparative Study of Clinical Outcomes, Patient Experiences, and Mechanistic Insights with Multimodality Imaging
['FUNDING_OTHER'] · CEDARS-SINAI MEDICAL CENTER · NIH-11135718
This study is looking at how two different treatments for degenerative mitral regurgitation—one done through a small tube and the other through traditional surgery—affect patients' health and experiences, so we can better understand which option might work best for you over time.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11135718 on ClinicalTrials.gov |
What this research studies
This research investigates the differences in clinical outcomes and patient experiences between two treatment options for degenerative mitral regurgitation: transcatheter edge-to-edge repair and traditional surgical repair. By following approximately 1,800 patients over a decade, the study aims to gather comprehensive data on the effectiveness, safety, and long-term results of each treatment. Patients will undergo multimodality imaging to assess their heart function and recovery, providing valuable insights into which approach may be more beneficial. The goal is to fill existing knowledge gaps and improve treatment decisions for patients with this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with severe degenerative mitral regurgitation, particularly those over 75 years old.
Not a fit: Patients with mild mitral regurgitation or those who are not candidates for either treatment option may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and better outcomes for patients with degenerative mitral regurgitation.
How similar studies have performed: While there have been advancements in treatment for mitral regurgitation, this research is novel as it aims to directly compare the two main treatment options in a large cohort over an extended period.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUPTA, AAKRITI — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: GUPTA, AAKRITI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Barlows Syndrome