Understanding heart muscle changes due to mitral valve problems
Mechanism of Eccentric Cardiomyocyte Hypertrophy Secondary to Mitral Regurgitation
['FUNDING_R01'] · UNIVERSITY OF UTAH · NIH-11075371
This study looks at how the heart changes when someone has mitral regurgitation, a common heart valve problem, and aims to understand why the heart can become enlarged and weak over time, which could help find better ways to treat patients with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF UTAH (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-11075371 on ClinicalTrials.gov |
What this research studies
This research investigates how the heart muscle adapts and changes in response to mitral regurgitation, a common heart valve disorder. It focuses on the molecular mechanisms that lead to heart muscle enlargement and dysfunction over time. By using advanced animal models, the research aims to uncover the underlying processes that contribute to heart failure in patients with severe mitral regurgitation. This knowledge could help develop better treatment strategies for managing this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with moderate to severe mitral regurgitation who are experiencing heart muscle changes.
Not a fit: Patients with mild mitral regurgitation or those without any heart valve disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from heart failure due to mitral regurgitation.
How similar studies have performed: Previous research has shown promise in understanding heart muscle changes in other forms of heart disease, but this specific approach to mitral regurgitation is relatively novel.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- UNIVERSITY OF UTAH — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DRAKOS, STAVROS GEORGE — UNIVERSITY OF UTAH
- Study coordinator: DRAKOS, STAVROS GEORGE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.