Better defining non-ischemic cardiomyopathy with functional mitral regurgitation to predict treatment outcomes
Improving Phenotypic Classification and Prediction of Treatment Outcomes in Patients with Non-ischemic Cardiomyopathy and Functional Mitral Regurgitation
The team will use advanced heart MRI to better classify people with non-ischemic cardiomyopathy and functional mitral regurgitation so doctors can predict which treatments may work best.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11319841 on NIH RePORTER |
What this research studies
You would get a detailed cardiac MRI to measure heart chamber size, pumping function, and tissue scarring more precisely than standard ultrasound. Researchers will combine those MRI results with clinical and outcome data to identify subtypes of non-ischemic cardiomyopathy and build models that predict how patients do after medical therapy or mitral valve procedures. The project focuses on linking imaging patterns to real outcomes like survival and symptom improvement to help guide treatment choices. The goal is clearer selection criteria for interventions such as percutaneous mitral repair (MitraClip) versus medical management.
Who could benefit from this research
Good fit: Adults with non-ischemic cardiomyopathy who have at least moderate functional mitral regurgitation and who can undergo cardiac MRI and clinical follow-up would be ideal candidates.
Not a fit: Patients whose mitral regurgitation is primarily degenerative (primary valve disease), those with ischemic-only cardiomyopathy without a non-ischemic component, or people unable to have MRI may not benefit directly from this work.
Why it matters
Potential benefit: If successful, this could help doctors choose the right timing and type of mitral valve treatment and improve survival and symptoms for patients with heart failure and functional mitral regurgitation.
How similar studies have performed: Prior trials like MITRA-FR and COAPT produced mixed results for percutaneous mitral repair, and using cardiac MRI to refine patient selection is promising but not yet proven.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Kwon, Deborah — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Kwon, Deborah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.