Improving treatment predictions for heart patients with mitral valve issues
Official title: Improving Phenotypic Classification and Prediction of Treatment Outcomes in Patients with Non-ischemic Cardiomyopathy and Functional Mitral Regurgitation
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11073111 · Data updated 2026-11-12
This study is looking at how to better understand and treat heart problems in people with non-ischemic cardiomyopathy and leaky heart valves, using advanced imaging techniques to help doctors choose the best treatments for each patient.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 10, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $707,106 |
| NIH project number | 5R01HL170090-03 |
| Project ID | NIH-11073111 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with non-ischemic cardiomyopathy and functional mitral regurgitation.
✕Less likely to help
Patients with ischemic cardiomyopathy or those without functional mitral regurgitation may not benefit from this research.
What this research studies
This research focuses on patients with non-ischemic cardiomyopathy and functional mitral regurgitation, conditions that can lead to serious heart problems. The study aims to enhance the classification of these conditions and predict treatment outcomes using advanced cardiac magnetic resonance imaging (CMR). By analyzing heart structure and function more accurately, the research seeks to establish better criteria for selecting patients for interventions like Mitraclip therapy. This approach could lead to more personalized treatment plans and improved patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment strategies for patients with heart failure and mitral valve issues, potentially reducing mortality rates.
How similar studies have gone: Previous studies have shown that advanced imaging techniques like CMR can significantly improve the understanding and treatment of heart conditions, indicating a promising avenue for this research.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Kwon, Deborah — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Kwon, Deborah
Related research
Other NIH-funded projects on the same topics.
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Better defining non-ischemic cardiomyopathy with functional mitral regurgitation to predict treatment outcomes
The team will use advanced heart MRI to better classify people with non-ischemic cardiomyopathy and functional mitral regurgitation so doctors can predict which treatments may work best.
-
Correcting cardiac microdomains to reverse non-ischemic heart failure
A gene therapy approach targeting calcium-handling microdomains in the heart is being tested to restore heart function in a large animal model of non-ischemic cardiomyopathy.
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Improving heart function by correcting calcium handling in heart cells
This study is testing a new gene therapy that aims to fix how heart cells manage calcium in people with non-ischemic cardiomyopathy, using minipigs to see if improving a specific protein can help the heart work better and stay healthier.
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Aims to test if delivering heart-cell–derived exosomes into damaged heart tissue can reduce scar and prevent dangerous ventricular rhythms in a porcine model of chronic ischemic cardiomyopathy.
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The team is testing whether tiny particles from heart-derived cells can repair scarred heart tissue and stop life-threatening ventricular rhythms in people with ischemic cardiomyopathy.
-
Improving heart tissue to prevent dangerous heart rhythms
This study is looking at a new way to help people with chronic heart issues by using tiny particles from heart cells to improve the heart's electrical signals and reduce scar tissue, making it safer and more effective for patients with dangerous heart rhythms.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.