Understanding Atrioventricular Regurgitation in ATTR Amyloid Cardiomyopathy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to characterize the prevalence and clinical outcomes of mitral and tricuspid regurgitation in patients diagnosed with transthyretin amyloid cardiomyopathy (ATTR-CM). It will develop new grading standards for assessing regurgitation severity that are tailored to the unique hemodynamic profile of ATTR-CM. By conducting a comprehensive baseline echocardiographic assessment, the study seeks to address the limitations of current classifications that do not adequately reflect the condition's pathophysiology.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of ATTR-CM according to current diagnostic criteria
* Comprehensive baseline echocardiographic assessment, including (semi-)quantitative mitral and tricuspid regurgitation (MR/TR) parameters, performed within ±6 months of diagnosis
* Age ≥ 18 years
* Willingness to participate in the study and provide informed consent

Exclusion Criteria:

* Severe aortic valve disease requiring intervention
* Inability to provide informed consent or participate in study follow-up

Where it's running

• Medical University of Graz
  Graz, Styria, Austria Recruiting
• Department of Internal Medicine II, Medical University of Vienna
  Vienna, Austria Recruiting
• Medizinische Klinik und Poliklinik I, Klinikum der Universitaet Muenchen, Ludwig-Maximilians-University
  Munich, Bavaria, Germany Recruiting
• Department of Cardiology, University Hospital Frankfurt, Goethe University
  Frankfurt am Main, Hesse, Germany Recruiting
• Institute of Cardiology, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia
  Brescia, Italy Recruiting
• Cardiologic Centre, Azienda Ospedaliero Universitaria di Ferrara
  Ferrara, Italy Recruiting

Study contacts

• Study coordinator: Christian Nitsche, Priv.-Doz. Dr., PhD
• Email: christian.nitsche@meduniwien.ac.at
• Phone: +4314040048590

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.